Comparing the Efficacy of Parecoxib and Ketorolac as Preemptive Analgesia in Patients Undergoing Posterior Lumbar Spinal Fusion
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Pain score
研究概览
简要总结
The purpose of this study is to evaluate the efficacy of Parecoxib and Ketorolac as a preemptive analgesia in patients undergoing lumbar spinal fusion.
详细描述
A prospective, double-blinded randomized control trial. Randomly allocated patient undergoing posterior lumbar spinal fusion into 3 groups (n=32) to receive Parecoxib, Ketorolac and Placebo around 30 minutes prior to incised skin. Efficacy was assessed by visual analog scale score (0-10), total opioid consumption, complication and bleeding also recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing lumbar spinal fusion for one to three levels
- •ASA class I or II
排除标准
- •History of allergy to Sulfa group
- •History of allergy to OPOID or NSAIDs
- •Contraindicate to NSAIDs use
- •History of coagulopathy or platelet disfunction
研究组 & 干预措施
Parecoxib
Parecoxib
干预措施: Parecoxib (Drug)
Ketorolac
Ketorolac
干预措施: Ketorolac (Drug)
结局指标
主要结局
Pain score
时间窗: Postoperative time up to 24 hours
recorded as Verbal Numerical Rating Scare 0-10
次要结局
- Total amount of opioid consumption postoperatively(Postoperative 24 hours)
研究者
KOOPONG SIRIBUMRUNGWONG, MD
Comparing the efficacy of Parecoxib and Ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion
Prince of Songkla University