Comparison of Ketorolac and Parecoxib for Postoperative Outcome in Total Knee Arthroplasty
Phase 3
Recruiting
- Conditions
- patient have knee pain with the diagnosis of osteoarthritis. The patient have been scheduled for unilateral total knee arthroplasty.Total knee arthroplasty,ketorolac,parecoxib
- Registration Number
- TCTR20170619007
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
patient have knee pain with the diagnosis of osteoarthritis. And the patient have been scheduled for unilateral total knee arthroplasty.
Exclusion Criteria
1. pregnant
2. had previous knee surgery
3. History of knee infection
4. allergy to medicine used in the trials
5. history of deep vein thrombosis
6. heart disease
7. cerebrovascular disease
8. peptic ulcer
9. kidney disease
10. liver disease
11. Hemoglobin less than 30 mg/dl
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score 6, 12,24, 48, 72, 96 hour postoperative Visual analoque scale,Degree of Knee flexion, Straight leg raising and extension lag 6, 12,24, 48, 72, 96 hour postoperative Goniometer,Morphine consumption 24, 48, 72, 96 hour postoperative amount of morphine use from PCA
- Secondary Outcome Measures
Name Time Method Perioperative blood loss preoperative and 24 hour postoperative Balance calculation method,Drainage blood loss 24, 48 hour postoperative Amount of blood discharge in drain,Renal function 6, 12,24, 48, 72, 96 hour postoperative Creatine clearance