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Clinical Trials/NCT00522496
NCT00522496
Unknown
Not Applicable

Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

University of Calgary1 site in 1 country8 target enrollmentJuly 2007
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ConditionsBrain Injuries, Traumatic

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Brain Injuries, Traumatic
Sponsor
University of Calgary
Enrollment
8
Locations
1
Last Updated
17 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The purpose of this study is to:

  1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury
  2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury
  3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.
Registry
clinicaltrials.gov
Start Date
July 2007
End Date
August 2009
Last Updated
17 years ago
Study Type
Observational
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Patient is 18 years of age or older
  • •Patient has GCS less than 9
  • •Patient requires intracranial pressure monitoring
  • •Patient life expectancy greater than 72 hours

Exclusion Criteria

  • •Patient's TBI is greater than 24 hours old
  • •Patient is less than 18 years of age
  • •Patient does not require intracranial pressure monitoring
  • •Patient has life expectancy less than 72 hours
  • •Patient has GCS greater or equal to 9
  • •Patient is currently enrolled in another study

Outcomes

Primary Outcomes

Not specified

Study Sites (1)

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