NCT00522496Unknown不适用
Proteomics of Severe Traumatic Brain Injury: A Feasibility Study
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 8
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to:
- Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury
- Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury
- Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient is 18 years of age or older
- •Patient has GCS less than 9
- •Patient requires intracranial pressure monitoring
- •Patient life expectancy greater than 72 hours
排除标准
- •Patient's TBI is greater than 24 hours old
- •Patient is less than 18 years of age
- •Patient does not require intracranial pressure monitoring
- •Patient has life expectancy less than 72 hours
- •Patient has GCS greater or equal to 9
- •Patient is currently enrolled in another study
研究者
研究点 (1)
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