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Clinical Trials/NCT05343247
NCT05343247
Completed
Not Applicable

Evaluation of Dental Age of Children With Amelogenesis Imperfecta Using Cameriere European Formula and London Atlas

Istanbul University1 site in 1 country416 target enrollmentMarch 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Amelogenesis Imperfecta
Sponsor
Istanbul University
Enrollment
416
Locations
1
Primary Endpoint
Correlation coefficient of Cameriere European formula.
Status
Completed
Last Updated
last year

Overview

Brief Summary

The aim of this study is to investigate whether there is a significant difference in dental age between children with amelogenesis imperfecta (AI) and healthy controls using Cameriere European formula and London Atlas. If there is a significant difference in dental age between children with AI and healthy controls, it is aimed to create a new formula.

Detailed Description

One of the developmental enamel defects, amelogenesis imperfecta (AI), is also known as enamel hypoplasia/hypomineralization. It is a rare inherited disease that affects the enamel structure, amount and component in primary and permanent teeth, and it has been reported to be accompanied by some dental anomalies and nephrocalcinosis. Dental anomalies and nephrocalcinosis can affect tooth development, and there are limited studies examining tooth development in these individuals.Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan. Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan. There are two basic approaches to dental age determination in children: 1. evaluation of eruption of teeth in the oral cavity, 2. evaluation of the development and mineralization of crowns and roots on dental radiographs. In many methods, the developmental stages of different numbers of permanent teeth are used. One of the most widely used methods of dental age determination recently is the European formula of Cameriere et al., which is calculated based on open apex. It has been reported that this method has been tested on different population groups, and the results are accurate and reliable. An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all the teeth array images of certain age groups as a schematic series. Age determination is made by deciding which reference image matches the individual's panoramic radiography image more.

Registry
clinicaltrials.gov
Start Date
March 1, 2022
End Date
April 23, 2024
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Yelda Kasımoğlu

Principal investigator

Istanbul University

Eligibility Criteria

Inclusion Criteria

  • 5-13 years old
  • Healthy children
  • Children with AI
  • Patients without missing left mandibular permanent teeth on panoramic radiography

Exclusion Criteria

  • Children older than 5 years old and younger than 14 years (children that cannot be assessed by the Willems and Cameriere method)
  • Poor quality panoramic radiography
  • Patients who have received orthodontic treatment
  • Patients who received restorative or endodontic treatment

Outcomes

Primary Outcomes

Correlation coefficient of Cameriere European formula.

Time Frame: day 1

Dental age of children with AI and healthy controls assessed by the correlation coefficient.

Correlation coefficient of London Atlas method.

Time Frame: day 1

Dental age of children with AI and healthy controls assessed by the correlation coefficient.

Secondary Outcomes

  • Dental age estimation in children with AI(day 1)

Study Sites (1)

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