Evaluation of Dental Maturation and Mandibular Bone Morphology in Childhood Rheumatic Diseases

Not Applicable

Completed

• Conditions: Childhood Rheumatic Diseases
• Interventions: Radiation: Panoramic rad.

• Registration Number: NCT05832359
• Lead Sponsor: Marmara University

Brief Summary

The aim of our study is to examine possible disease-related changes in dental age and mandibular bone morphology in childhood rheumatic diseases.

Detailed Description

to reveal the changes that can occur in different childhood rheumatic diseases, the treatment process of the disease and the drugs used on the dental age and mandible

Study Timeline

• Study First Submitted: 2022-12-14
• Study First Submitted QC: 2023-04-26
• Study First Posted: 2023-04-27
• Study Start: 2023-05-19
• Status Verified: 2023-12
• Primary Completion: 2023-12-01
• Study Completion: 2023-12-05
• Last Update Submitted: 2023-12-05
• Last Update Posted: 2023-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 278

Inclusion Criteria

• Patients aged 6 to 14 years with childhood rheumatism
• Patients without bilateral congenital germ deficiency in the lower teeth
• Patients with seven teeth (except no #8) on the left of the mandibula (No seven teeth on the left of the mandibula, there should be a symmetrical tooth on the right of the mandibula.

Exclusion Criteria

• Patients with bilateral congenital germ deficiency in lower teeth in intraoral and/or radiographic examinations
• Patients with asymmetry and magnification errors and where anatomical structures cannot be seen clearly in the panoramic x-ray
• Patients with a significant number of missing teeth due to trauma or disease, root canal treatment, and pathological tooth structure
• Patients with a history of other chronic diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy children	Panoramic rad.	-
Children diagnosed with childhood rheumatic disease	Panoramic rad.	-

Primary Outcome Measures

Name	Time	Method
Dental Age Estimation	3 months	The study group will be comprised of newly diagnosed pediatric patients who applied to Umraniye Training and Research Hospital Division of Pediatric Rheumatology and whose treatment is ongoing, and the control group will be composed of pediatric patients without systemic disease who applied to Marmara University Faculty of Dentistry Department of Pedodontics. In the study, digital panoramic x-rays of the patients will be evaluated and dental age estimation with Willems method will be made.

Secondary Outcome Measures

Name	Time	Method
Mandibular bone morphometric measurements	3 months	The study group will be comprised of newly diagnosed pediatric patients who applied to Umraniye Training and Research Hospital Division of Pediatric Rheumatology and whose treatment is ongoing, and the control group will be composed of pediatric patients without systemic disease who applied to Marmara University Faculty of Dentistry Department of Pedodontics.For mandibular bone morphometric measurements, fractal analysis, that is a mathematical method describing and analyzing complex shapes and structural patterns such as the bone tissue, will be used in order to assess the bone density, using Image J software. A region of interest will be selected from panoramic radiographs. Image processing will be applied to correct for lightning irregularity, and box-counting method will be used to calculate a fractal dimension.

Trial Locations

Locations (1)

Ecem Ipek; 🇹🇷 Istanbul, Turkey