Effect of Trans Nasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) During Apneic Oxygenation in General Anesthesia on Biomarkers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Oxidative stress
研究概览
简要总结
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as biological stress response detected by blood-bourne biomarkers before implementing it into clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults, >18 years old.
- •Laryngeal-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery).
- •Capable of understanding the study information and sign the written consent.
排除标准
- •American Society of Anaesthesiologist severity score >2
- •New York Heart Association score >2
- •Pacemaker or ICD.
- •Body Mass Index >35
- •Manifest cardiac failure or coronary disease
- •Severe gastrointestinal reflux.
- •Neuromuscular disorder
结局指标
主要结局
Oxidative stress
时间窗: Up to 2 hours after start of intervention
Biomarkers of oxidative stress such as Thiobarbituric acid reactive substances, Advanced Oxidation Protein Products,Reactive oxygen species and total antioxidant capacity in blood samples
次要结局
- Inflammatory response(Up to 2 hours after start of intervention)
- Biomarkers of cardiac damage(Up to 2 hours after start of intervention)
- Biomarkers of neuronal injury(Up to 2 hours after start of intervention)
- Biomarkers of kidney injury(Up to 2 hours after start of intervention)
- Markers of RNA damage(Up to 2 hours after start of intervention)
研究者
Malin Jonsson Fagerlund
Senior Consultant, Associate Professor
Karolinska University Hospital