Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)

Recruiting

• Conditions: Glossopharyngeal Neuralgia; Pulsed Radiofrequency; Platelet Rich Plasma

• Registration Number: NCT06931457
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

To investigate the efficacy and safety of the application of PRF combined PRP to the for the treatment of GPN.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-04-15
• Study First Submitted QC: 2025-04-15
• Study First Posted: 2025-04-17
• Study Start: 2025-05-01
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-01
• Last Update Posted: 2025-07-03
• Primary Completion: 2027-05-01
• Study Completion: 2027-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

1. age >18 years;
2. diagnosed with idiopathic GPN according to the third International Classification of Headache Disorders (ICHD) classification;
3. patients who failed pharmacotherapy or intolerable side effects of medication;
4. undergoing PRF for GPN;
5. at least 1 month of follow-up recordings.

Exclusion Criteria

1. Patients with bilateral GPN;
2. Abnormalities in blood measurements, liver and kidney function, blood glucose, coagulation, electrocardiography or chest radiography;
3. Infection at the puncture site;
4. Previous mental illness;
5. Previous history of narcotic drug abuse;
6. Prior anticoagulant or antiplatelet therapy;
7. An implantable pulse generator;
8. Current pregnancy or breast feeding.
9. Patients with incomplete medical records (lack of baseline data or postoperative follow-up data).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Numeric rating scale (NRS) score	1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure	Numeric rating scale (NRS) score during resting was used to evaluate pain intensity before and after PRF treatment (0=no pain, 10=intolerable pain)

Secondary Outcome Measures

Name	Time	Method
Barrow Neurological Institute pain scale(BNI score)	1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure	BNI score during resting was used to evaluate pain relief

Trial Locations

Locations (1)

Beijing Tiantan Hospital; 🇨🇳 Beijing, Beijing, China