Brain research in Whiplash Associated Disorder

Completed

• Conditions: whiplash; craniocervical acceleration trauma; 10028393

• Registration Number: NL-OMON35947
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Females, between 18 and 45 years.
Right-handed
Body Mass Index equal/less than 29
For patients:
Rear end automobile collision
Whiplash Associated Disorder (WAD) classified as grade I or II
At least 2 years from the accident, up to 10 years.
No treatment for WAD other than painkillers

Exclusion Criteria

Pregnant or in menopause.
Use of anticoagulants, medication that affect the immune system or investigation drug.
Current or recent alcohol or substance abuse.
Current or recent infectious, inflammatory, metabolic or systemic disease.
Impossibility to perform a PET scan (claustrophobia...)
Diagnosis of Depression or Anxiety.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective is to compare regional cerebral blood flow (rCBF) in<br /><br>response to non-painful neck stimulus, between patients with WAD and healthy<br /><br>matched control volunteers, ascertained by Positron Emission Tomography (PET)<br /><br>scan. Each subject will be exposed to four different conditions: rest state,<br /><br>placebo-like stimuli, low intensity stimuli, and high intensity neck stimuli.<br /><br>The rCBF corresponding to exposure to each stimulus is measured in the brain by<br /><br>PET.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objective is to determine if there is a correlation between rCBF<br /><br>response and the results in the questionnaires.</p><br>