HDL Dysfunction During the Acute Stage of Stroke

• Conditions: Stroke, Acute
• Interventions: Other: Haemorrhagic stroke; Other: Ischemic stroke

• Registration Number: NCT03245957
• Lead Sponsor: Centre Hospitalier Universitaire de la Réunion

Brief Summary

The study investigates the effect of plasma myeloperoxidase (MPO) concentrations on HDL dysfunction during the acute stage of ischemic and haemorrhagic strokes.

Detailed Description

MRI or CT scan are used to confirm the diagnosis of haemorrhagic, ischemic and mimick stroke.

Plasma anf HDL-MPO concentrations, as well as potent HDL dysfunction, are compared in the 3 cases.

The investigators hypothesis is that MPO concentrations and subsequent HDL dysfunction could be higher in ischemic strokes than in haemorrhagic ones. MPO could be a examined as a potent marker of early stage of ischemic stroke.

Plasma MPO levels could also be discriminant regarding the mimick strokes in patient exhibiting stroke clinical picture.

Study Timeline

• Study First Submitted: 2017-08-08
• Study First Submitted QC: 2017-08-08
• Study First Posted: 2017-08-10
• Study Start: 2017-10-20
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-06
• Last Update Posted: 2019-03-07
• Primary Completion: 2019-10
• Study Completion: 2020-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

Patients with less than 12 hours stroke clinical signs:

• hemiparesis or hemiplegia
• unilateral sensitivity disorder
• language impairment
• balance disorder
• dizziness, bilateral or monocular vision totally or partially lost

Exclusion Criteria

• Pregnancy
• head trauma since the last 3 months
• stroke since the last 3 months
• myocardial infarction since the last 3 months
• patient disagrees to be enrolled in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Haemorrhagic stroke	Haemorrhagic stroke	Patients without haemorrhagic stroke diagnosed by MRI or CT scan
Ischemic stroke	Ischemic stroke	Patients with ischemic stroke diagnosed by MRI or CT scan

Primary Outcome Measures

Name	Time	Method
Plasma MPO concentrations	Through study completion, an average of 6 hours	Assessment of plasma MPO concentrations during acute stage of stroke

Secondary Outcome Measures

Name	Time	Method
HDL-MPO concentrations	Through study completion, an average of 6 hours	Assessment of HDL-MPO concentrations during acute stage of stroke

Trial Locations

Locations (1)

Chu Reunion Island; 🇷🇪 Saint-Pierre, Reunion Island, Réunion