Comparison of the effectiveness of oxytocin nasal spray with placebo on symptoms and treatment of adults with autism: a randomized clinical trial

Tehran University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新: 2022年3月8日

适应症

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•Age between 16 years and zero months to 55 years and 11 months
•Confirmation of diagnosis by a psychiatrist based on dsm5
•Complete physical examination and normal laboratory tests
•Ability to understand and speak Persian fluently
•Ability to read and understand the consent form in full and if it is not possible for the legal guardian to read and sign the form
•Clinical global impression-severity CGI-S score above 4 in screening
•Intelligence score in Stanford test - above 75

•Patients with nasal septal deformity and previous epithelial injuries and a history of nasal surgeries with a risk of nasal epithelium damage and people with a history of inhaled substance use
•Patients with nasal congestion due to colds
•Patients in the acute phase of psychiatric illness or with thoughts of death and suicide
•Having a history of neurological diseases, seizures and head injuries
•People with a history of neurological or metabolic disease that affects their sensory and motor function, etc.
•Receive stimulant medications
•History of uncontrolled cardiovascular, renal and hepatic diseases
•Pregnant women or young women who do not take oral contraceptives
•People whose type and dose of psychiatric medication have changed in the last 4 weeks
•People with a history of chronic oxytocin treatment
•History of allergy to oxytocin and syntocinin and all its compounds

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