Comparison between dexmedetomidine and midazolam for emergence agitation after nasal surgeries

This is randomised comparison between two drugs, Inj Midazolam and Inj Dexmedetomidine for prevention of emergence agitation following nasal surgeries.  After obtaining valid informed consent patients will receive drug as per allotment group. For Group I, 100 mcg of Inj dexmedetomidine would be added into normal saline to make total volume of 50 mL. For Group II, 5 mg of inj midazolam would be added to normal saline to make total of 50 mL. Infusions will be started as per mentioned earlier. All standard monitors would be connected and vitasl will be monitored as mentioned in outcomes. General anaesthesia will be induced with inj propofol 2mg/kg, Fentanyl 2mcg/kg and vecuronium 0.1 mg/kg.  Patients will be intubated with appropriate size entotracheal tube and will be maintained with oxygen , nitrous oxide, sevoflurane and inj vecuronium for relaxation. Additional analgesia will be decided by anaesthesiologist assigned to the case. Infusion and inhalational agents will be stopped at end of surgery when nasal packing is started. total duration of inhalational agent and time of discontinuation would be noted. Time from discontinuation to eye opening would be noted. patients would be reversed and extubated. Agitation score would be seen as per ’Riker’s agiatation sedation score’( RASS). Score of 5 and above will be taken as agitation and score of 3 and below will be taken as sedation.Patients would be monitored with same scale every 5 minutes for half an hour and then every 15 minutes for 2 hours.