Asthma: a disease due to a lack of bacterial infections in childhood
Not Applicable
- Conditions
- Atopic disease, asthmaRespiratoryAsthma
- Registration Number
- ISRCTN54378178
- Lead Sponsor
- niversity Medical Centre Utrecht (UMCU) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
High-risk newborns. High-risk was defined as either a mother or a father plus a sibling with present or past atopic disease.
Exclusion Criteria
1. Maternal infection in the last week of pregnancy
2. The use of immunomodulatory drugs or antibiotics during pregnancy (mother)
3. The use of antibiotics prenatally (mother and newborn)
4. Prematurity
5. Signs of intra-uterine infection
6. Premature rupture of membranes
7. Presence of congenital disorders of the airways
8. Sever other congenital disorders
9. Need for mechanical ventilation
10. Prolonged administration of extra oxygen
11. Need for intensive care treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence and severity of atopic disease at the age of 4 years.
- Secondary Outcome Measures
Name Time Method <br> 1. SCORing Atopic Dermatitis (SCORAD)<br> 2. Lung function<br> 3. Cytokine production<br> 4. Natural Resistance Associated Macrophage Protein (NRAMP) polymorphisms<br>