Respiratory infections in asthma: the role of host defense against infections, allergic inflammation and vitamin D

• Conditions: asthma; 10001708; 10004018; 10006436

• Registration Number: NL-OMON31956
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

-Age 18-45 yrs
-BMI< 27
-History of episodic symptoms of wheezing, breathlessness, cough or chest tightness (>12 months)
-FEV1>70 % of predicted
-Hyperresponsive in standard methacholine challenge (PC20methacholine< 9,6 mg/ml)
-Atopic, as reflected by one or more wheal (> 3 mm) response to skin prick test (SPT) with 10 common airborne allergen extracts (HAL)

Exclusion Criteria

-Age <18 yrs or > 45 yrs
-BMI> 27
-Smoking or ex-smoking (for less than 12 months > 5 pack years)
-Usage of inhaled or nasal corticosteroids within last 4 weeks or oral corticosteroids within 3 months prior to and during the study
-Usage of vitamin D supplements
-Pragnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- antimicrobial peptides in nasal secretions and sputum<br /><br>- 1,25 (OH) vitamin D in serum<br /><br>- mediators of allergic inflammation in nasal secretions and sputum</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- sputum cell differentials<br /><br>- bacterial and viral load<br /><br>- 25 (OH) vitamin D in serum<br /><br>- exhaled NO-measurements<br /><br>- PTH levels</p><br>