The Effect of Intracameral Cefuroxime on Post-op Fibrin in Pediatric Cataract Surgery

Not Applicable

Completed

• Conditions: Cataract; Endophthalmitis
• Interventions: Drug: cefuroxime; Drug: Saline placebo

• Registration Number: NCT00730938
• Lead Sponsor: Presbyterian Church East Africa Kikuyu Hospital

Brief Summary

The study investigates whether placing an antibiotic inside the eye at the end of cataract surgery in children will reduce the amount of fibrin formation (fibrin formation can block the pupil and reduce vision). We hypothesize that the fibrin is caused by a low-level infection and could be prevented by the antibiotic.

Detailed Description

The study investigates whether using an antibiotic (cefuroxime) in the anterior chamber of the eye at the end of surgery for cataract in children will reduce the amount of fibrin formation.

Study Timeline

• Study Start: 2008-02
• Primary Completion: 2008-07
• Status Verified: 2008-08
• Study Completion: 2008-08
• Study First Submitted: 2008-08-05
• Study First Submitted QC: 2008-08-07
• Last Update Submitted: 2008-08-07
• Study First Posted: 2008-08-08
• Last Update Posted: 2008-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• bilateral congenital or developmental pediatric cataract

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Exclusion Criteria

• traumatic cataract

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	cefuroxime	-
2	Saline placebo	Saline placebo

Primary Outcome Measures

Name	Time	Method
Fibrin formation in anterior chamber	4th postoperative day

Trial Locations

Locations (1)

Presbyterian Church East Africa Kikuyu Hospital; 🇰🇪 Kikuyu, Kenya