Resuscitation for repair of endothelial permeability in endotoxemia

Phase 2

Recruiting

• Conditions: blood poisoning; Sepsis; 10002252

• Registration Number: NL-OMON52233
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

- Healthy male volunteer
- Between 18-35 years old
- BMI between 20-25

Exclusion Criteria

- No informed consent
- Use of medication on prescription - Blood donation < 3 months
- Previous blood transfusion
- Participation in other medical study < 3months
- Participation in previous volunteer studies using LPS in the past year
- Fever at the intake or on research day (T > 38.5)
- Known allergic reaction to albumin

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Levels of soluble syndecan-1</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Levels of endothelial permeability, such as sTM, vWF, A13 antigen and<br /><br>activity.<br /><br>- Blood count and coagulation tests (Hb, WBC, platelet count, PT, fibrinogen,<br /><br>Ddimer, AT)<br /><br>- Markers of tissue oxygenation such as lactate, NIRS, mitoPo2<br /><br>- Markers of tissue perfusion such as SDF, cardiac output<br /><br>- Physiologic measurements (MAP, heart rate, temperature)<br /><br>- Arterial pulse wave morphology and non invasive cardiac output</p><br>