Exercise in Breast Cancer Survivors: Analysis of Angiogenic Profile
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- University of Mississippi Medical Center
- Locations
- 1
- Primary Endpoint
- Number of participants that complete the study as a measure of feasibility of an exercise intervention in obese breast cancer survivors.
- Status
- Withdrawn
- Last Updated
- 11 years ago
Overview
Brief Summary
The investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. Exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.
Investigators
Natale Sheehan
Assistant Professor of Medicine
University of Mississippi Medical Center
Eligibility Criteria
Inclusion Criteria
- •\> 18 years of age and \< 65 years of age
- •BMI \> 25
- •Weight \< 350 pounds
- •English as a primary language
- •Postmenopausal
- •Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy
- •Received and Completed standard of care adjuvant therapy (Concurrent endocrine therapy acceptable)
- •6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization
Exclusion Criteria
- •Recurrent breast cancer
- •DCIS only (no invasive component)
- •Taking a Beta Blocker or Verapamil
- •Wheelchair bound
- •Unable to ambulate independently
- •Concurrent uncontrolled medical or psychiatric disorder
- •Open wound
- •Stage IV breast cancer
- •Progression of disease
- •Bilateral mastectomies
Outcomes
Primary Outcomes
Number of participants that complete the study as a measure of feasibility of an exercise intervention in obese breast cancer survivors.
Time Frame: 12 months
Number of participants that enroll in the study and actually complete the study
Secondary Outcomes
- Amount of adipose tissue mass as measured on CT scans in obese breast cancer survivors before and after exercise intervention as a measure of weight loss(12 months)
- IGF-1, endostatin, and VEGF levels in obese breast cancer survivors undergoing an exercise intervention as a measure of angiostatic phenotype:(12 months)