Comparing an Early Protocolized Rehabilitation versus usual care in improving functional outcomes in Pediatric Neurocritical Patients of age 1-18 years

Not Applicable

Conditions: Health Condition 1: G00-G99- Diseases of the nervous system

Registration Number: CTRI/2021/11/038180

Lead Sponsor: AIIMS Rishikesh

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Closed to Recruitment of Participants

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. Children between ages 1 and 18 years

2. Satisfying operational definition for neurocritical patient

3. Premorbid Pediatric Cerebral Performance Category (PCPC) score of 1 or 2 within 2 weeks of onset of illness

Pediatric Neurocritical Patients (PNP) for the purpose of the study will be defined as:

I. Suffering from primary neurological illness with PCPC score of 3-5 at enrollment (or)

II. Suffering from any other systemic illness on invasive or non-invasive mechanical ventilation with

a. Evidence of metabolic, septic or hypertensive encephalopathy not completely reversible within 72 hours

b. Coexisting predisposing factors towards hypoxic-ischemic encephalopathy (OI >15, OSI >7.5, requiring any CPR)

Exclusion Criteria

1. Expected survival <24 hours (PSOFA score >20)

2. Children with absence of brain stem reflexes (PCPC score of 6)

3. Children requiring mechanical ventilation only during a perioperative period or for a period under the effect of sedatives/anesthetics for diagnostic procedures

4. Catecholamine refractory shock for >48 hours during initial 72 hours of mechanical ventilation

5. Major surgery involving vital internal organs performed or being planned within 24 hours

6. Active bleeding severe enough to be life threatening or cause hemodynamic instability

7. Uncontrolled raised intracranial pressure

8. Uncontrolled status epilepticus

9. Rapidly progressive neurodegenerative disease

10. Already received mechanical ventilation for >72 hours

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare childrenâ??s functional outcome at 12 weeks as assessed by Pediatric Cerebral Performance Category (PCPC) between the EPR and usual care arm.Timepoint: 12 week

Secondary Outcome Measures