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临床试验/NCT07412639
NCT07412639已完成不适用

Differential Effects of Tabata Exercise on Nitric Oxide Synthases and Maresin in Smokers and Non-Smokers

Ataturk University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年10月24日最近更新:
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
40
试验地点
1
主要终点
serum inducible nitric oxide synthase (iNOS) level

研究概览

简要总结

Smoking causes chronic inflammation and endothelial dysfunction through alterations in nitric oxide synthase (NOS) pathways. Maresin is an anti-inflammatory pro-resolving lipid mediator that plays important roles in the resolution of inflammatory processes. Tabata exercise is a short-duration, high-intensity exercise modality with beneficial effects on the cardiovascular system. The aim of this study was to comparatively evaluate the effects of tabata exercise on iNOS, eNOS, and Maresin levels, as well as the relationships among these biomarkers, in smokers and non-smokers.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Age between 18 and 40 years
  • No regular participation in structured physical exercise for at least 6 months prior to enrollment
  • Absence of any acute or chronic inflammatory disease at baseline
  • No history of cardiovascular, metabolic, pulmonary, or neurological disorders
  • Ability to comply with the study protocol and complete the tabata exercise program
  • Provision of written informed consent

排除标准

  • Initiation or cessation of smoking during the study period
  • Use of anti-inflammatory, antioxidant, corticosteroid, or vasoactive medications
  • Acute infection, surgical intervention, or major trauma within the preceding 3 months
  • Diagnosis of diabetes mellitus, hypertension, coronary artery disease, or chronic pulmonary disease
  • History of alcohol or substance abuse
  • Pregnancy or breastfeeding
  • Musculoskeletal or orthopedic conditions that could limit participation in tabata exercise
  • Inability to adhere to the exercise protocol or failure to complete follow-up assessments

研究组 & 干预措施

Smoker

Active Comparator
  • Current smokers with a smoking history of at least 2 years
  • Daily cigarette consumption of ≥10 cigarettes per day

干预措施: Tabata Exercise Protocol (Other)

Nonsmoker

Active Comparator
  • Individuals who had never smoked, or
  • Individuals who had not smoked for at least 5 years, with no history of regular passive smoking exposure

干预措施: Tabata Exercise Protocol (Other)

结局指标

主要结局

serum inducible nitric oxide synthase (iNOS) level

时间窗: 6 week after exercise

iNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.

serum inducible nitric oxide synthase (iNOS) level

时间窗: 12 week after exercise

iNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.

serum endothelial nitric oxide (eNOS) synthase level

时间窗: 6 week after exercise

eNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.

serum endothelial nitric oxide (eNOS) synthase level

时间窗: 12 week after exercise

eNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.

次要结局

  • serum maresin level(6 week after exercise)
  • serum maresin level(12 week after exercise)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Zafer Bayraktutan

Principal Investigator

Ataturk University

研究点 (1)

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