Differential Effects of Tabata Exercise on Nitric Oxide Synthases and Maresin in Smokers and Non-Smokers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- serum inducible nitric oxide synthase (iNOS) level
研究概览
简要总结
Smoking causes chronic inflammation and endothelial dysfunction through alterations in nitric oxide synthase (NOS) pathways. Maresin is an anti-inflammatory pro-resolving lipid mediator that plays important roles in the resolution of inflammatory processes. Tabata exercise is a short-duration, high-intensity exercise modality with beneficial effects on the cardiovascular system. The aim of this study was to comparatively evaluate the effects of tabata exercise on iNOS, eNOS, and Maresin levels, as well as the relationships among these biomarkers, in smokers and non-smokers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 40 years
- •No regular participation in structured physical exercise for at least 6 months prior to enrollment
- •Absence of any acute or chronic inflammatory disease at baseline
- •No history of cardiovascular, metabolic, pulmonary, or neurological disorders
- •Ability to comply with the study protocol and complete the tabata exercise program
- •Provision of written informed consent
排除标准
- •Initiation or cessation of smoking during the study period
- •Use of anti-inflammatory, antioxidant, corticosteroid, or vasoactive medications
- •Acute infection, surgical intervention, or major trauma within the preceding 3 months
- •Diagnosis of diabetes mellitus, hypertension, coronary artery disease, or chronic pulmonary disease
- •History of alcohol or substance abuse
- •Pregnancy or breastfeeding
- •Musculoskeletal or orthopedic conditions that could limit participation in tabata exercise
- •Inability to adhere to the exercise protocol or failure to complete follow-up assessments
研究组 & 干预措施
Smoker
- Current smokers with a smoking history of at least 2 years
- Daily cigarette consumption of ≥10 cigarettes per day
干预措施: Tabata Exercise Protocol (Other)
Nonsmoker
- Individuals who had never smoked, or
- Individuals who had not smoked for at least 5 years, with no history of regular passive smoking exposure
干预措施: Tabata Exercise Protocol (Other)
结局指标
主要结局
serum inducible nitric oxide synthase (iNOS) level
时间窗: 6 week after exercise
iNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.
serum inducible nitric oxide synthase (iNOS) level
时间窗: 12 week after exercise
iNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.
serum endothelial nitric oxide (eNOS) synthase level
时间窗: 6 week after exercise
eNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.
serum endothelial nitric oxide (eNOS) synthase level
时间窗: 12 week after exercise
eNOS level were quantified using immunosorbent assay (ELISA) kits, according to the manufacturers' instructions.
次要结局
- serum maresin level(6 week after exercise)
- serum maresin level(12 week after exercise)
研究者
Zafer Bayraktutan
Principal Investigator
Ataturk University