Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Chinese Medical Association
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- gege
Study Overview
Brief Summary
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Study Design
- Study Type
- Observational
- Observational Model
- Family Based
- Time Perspective
- Other
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;
Exclusion Criteria
- •Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms
Outcomes
Primary Outcomes
gege
Time Frame: 2023
Discovery of known or unknown genes
Secondary Outcomes
No secondary outcomes reported
Investigators
Zaiping Jing
professor
Chinese Medical Association