THE EFFECT OF EXTERNAL LEG COMPRESSION ON THE REDUCTION OF FLUID DEMAND IN MECHANICALLY VENTILATED PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK

Recruiting

• Conditions: Severe sepsis or severe blood poisoning; 10019815

• Registration Number: NL-OMON41683
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Age >18 years, <80 years
- Severe sepsis or sepsis shock
- Mechanically ventilated
- Picco Monitoring
- Written informed consent from legal representatives

Exclusion Criteria

- Morbid obese defined as BMI > 35 kg/m2;
- Death appearing imminent at admission (predicted in less than 24 hours)
- Pregnancy
- Injury or trauma of legs
- Burns of surface areas of legs
- Visible ulcers and known peripheral arterial insufficiency of legs;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cumulative fluid balance over first 3 days.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Global hemodynamic parameters (heart rate, blood pressure, central venous<br /><br>pressure and cardiac output),, vasopressor need, number of ventilator free<br /><br>days, length of stay in the ICU and in the hospital, and SOFA scores. </p><br>