The effect of lower body negative pressure on cerebral autoregulation in young and elderly healthy volunteers
Recruiting
- Conditions
- orthostasis1004225810011954
- Registration Number
- NL-OMON33320
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- age: 18-35 years and >70 years
- non-smoking
- body mass index: 18-28 kg/m2
- length: 160-190 cm
Exclusion Criteria
- medical history of cardiovascular disease, diabetes mellitus, pulmonary disease, neurological disease, malignant disease, venous insufficiency
- alcohol use >3 units / day
- use of systemic medication
- cognitive impairment (MMSE score < 28 points)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in (regional) cerebral blood flow and cerebral blood volume.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Cerebral blood flow velocity of main feeding cerebral arteries, continuous<br />blood pressure and heart frequency.</p>