Ketofol or Propofol, agent maintaining better haemodynamics in patients undergoing trans-sphenoidal pituitary surgery under total intravenous anaesthesia.
- Conditions
- Benign neoplasm of other specifiedparts of central nervous system, (2) ICD-10 Condition: G938||Other specified disorders of brain,
- Registration Number
- CTRI/2022/01/039533
- Lead Sponsor
- AIIMS
- Brief Summary
Although there have been many studies on role of various intravenous anaesthetic agents on maintenance of intraoperative haemodynamics in neurosurgical patients but there has not been many studies comparing their role on maintenance of cerebral oxygenation. So, we plan to conduct this study to compare the effects of two anaesthetic regimen on cerebral oxygenation in patients undergoing TNTS pituitary surgery. In TNTS pituitary surgery the surgical approach is via transnasal and transsphenoidroute. This avoids open craniotomy with the advantage ofavoidance of major handling of brain tissue (like retractor applications) and intracranial vessels, thereby minimizing the effects of surgical factors on cerebral oxygenation. We hypothesize that use of ketofol as induction & maintenance agent will lead to better cerebral oxygenation compared to Propofol alone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- All
- Target Recruitment
- 50
ASA 1, 2 Planned for elective endoscopic TNTS Pituitary Surgery.
Consent not given Patients with history of previous pituitary surgery Patients with psychiatric disorder History of drug abuse Poorly controlled hypertension Ischaemic heart disease, valvular heart disease History of lung diseases-COPD, Asthma History of Renal diseases History of liver diseases Pituitary apoplexy Morbidly obese ( BMI >40) Pregnant patients History of allergy to any of the planned anaesthetic medications of the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare effects of ketofol versus propofol on cerebral oxygenation (rSO2) in patients undergoing TNTS Pituitary surgery Baseline then Every 30min interval
- Secondary Outcome Measures
Name Time Method To compare between both drugs intraoperative haemodynamic parameters ( HR, MAP), intraoperative requirements of propofol and opioids, postoperative emergence Baseline & every 30min
Trial Locations
- Locations (1)
AIIMS, New Delhi
🇮🇳Delhi, DELHI, India
AIIMS, New Delhi🇮🇳Delhi, DELHI, IndiaDr Sudeshna PadhiPrincipal investigator9674858350drsud456@gmail.com