Determine if elevated level of bacteria in the blood is associated with increased risk of death

Not Applicable

Recruiting

• Conditions: Septic Shock; Infection - Studies of infection and infectious agents; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12611000637943
• Lead Sponsor: Infectious Disease and Microbiology, Westmead Hosptial

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patients will be eligible for inclusion in BLISS if they meet all of the following criteria:
1. Patient has been enrolled in the ARISE Study and less than 2 hours has elapsed since the time of randomisation into ARISE.
2. Patient has or will receive an arterial line

Exclusion Criteria

Same as ARISE exclusion criteria:
age < 18 years, pregnancy, central venous catheterisation or blood transfusion contraindicated, haemodynamic instability due to active bleeding, underlying disease process with a life-expectancy < 90 days, inevitable imminent death, any limitation-of-therapy order, or refused consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All cause mortality assessed[90 days after enrolment in the ARISE study];Bacterial load on presentation to hospital and changes in bacteraemic load over time will be assessed by blood analysis using multiplexed PCR technology.[For that admission]

Secondary Outcome Measures

Name	Time	Method
1. Organ failure as determined by the Sequential Organ Failure Assessment (SOFA) method[For that admission];ICU Survival[For that admission];Hospital Survival[For that admission]