Economic and Social Benefits of Treating and Preventing Influenza in Aged Care Facilities

Phase 4

Recruiting

• Conditions: Influenza outbreak in an aged-care facility; Respiratory - Studies of infection and infectious agents

• Registration Number: ACTRN12606000278538
• Lead Sponsor: The University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-07-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3200

Inclusion Criteria

Adult residents residing in a participating aged-care facility during an influenza outbreakStaff member in a participating aged-care facility during an influenza outbreak Volunteers and unpaid carers in a participating aged-care facility during an influenza outbreak who regularly spend substantial time being in contact with residents.

Exclusion Criteria

People who have a contraindication to oseltamivirStaff members and volunteers/ carers who are pregnantPatients undergoing dialysis for end stage renal disease or whose creatinine clearance is estimated to be 10ml/min or lessPeople who have symptoms of influenza for more than 48 hours will be ineligible to receive treatment with oseltamivir.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Attack rate of influenza in staff/residents of an aged-care facility in an outbreak[]

Secondary Outcome Measures

Name	Time	Method
Death within 4 weeks from onset of influenza symptoms of patient & case fatality rate within 4 weeks from onset of the outbreak[];Pneumonia incidence within 4 weeks from onset of influenza symptoms of patient[];Hospital admission incidence within 4 weeks from onset of influenza symptoms of patient[];Staff absenteeism during the outbreak[];Development of oseltamivir resistant influenza during the course of treatment or prophylaxis[];Adverse events following oseltamivir within 4 weeks from commencing course[];Duration of each outbreak/time to cessation of outbreak[];Quality of life of participants (assessed by EQ-5D) before and 4–6 weeks after onset of the outbreak[]