the Impact of Noise on Requirements of Anesthetics During General Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Technische Universität Dresden
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Requirements of the Inhalational Anesthetic Desflurane, Measured in Expiratory Volume Percentage, to Maintain a BIS-Index Triggered Depth of Anesthesia
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators hypothesize that the noise level in the operating theatre influences the patients' requirements of anesthetics. Study subject are patients undergoing abdominal surgery in combined general and epidural anesthesia. Analgesia is maintained by epidural injections of sufentanil and ropivacaine whereas general anesthesia is maintained using the inhalational anesthetic desflurane. Desflurane requirements are adjusted using neuromonitoring (BIS-Index). Intraoperative noise levels are recorded. Patients are randomized to receive hearing protections or not.
Detailed Description
All patients receive standardized anesthesia and monitoring according to the usual clinical care in the department. Placement of epidural catheters takes place before induction of general anesthesia. Thereafter, 10 ml ropivacaine 0.3% with 10 µg sufentanil are administered epidurally every 60 min to induce and maintain analgesia during surgery. Following induction of general anesthesia and tracheal Intubation, intraoperative hypnosis is maintained using desflurane.
Investigators
Eligibility Criteria
Inclusion Criteria
- •full contractual capability
- •written informed consent
- •abdominal surgery in combined general/epidural anesthesia
- •position during surgery: supine
- •clinically normal hearing
Exclusion Criteria
- •history of psychiatric disease
- •history of intraoperative awareness
- •clinically impaired Hearing
- •contraindication for placing an epidural catheter
Outcomes
Primary Outcomes
Requirements of the Inhalational Anesthetic Desflurane, Measured in Expiratory Volume Percentage, to Maintain a BIS-Index Triggered Depth of Anesthesia
Time Frame: one hour
Aimed BIS-index is 50, desflurane is measured in expiratory volume percentage
Secondary Outcomes
- Awareness Using a Structured Interview ("Modified Brice Questionnaire")(1 day)