The role of FTO Gene Variants on Metabolic Flexibility and Training Adaptations following a 12 Week High Intensity Exercise Interventio

Not Applicable

• Conditions: Metabolic Flexibility; Overweight and Obesity; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Diet and Nutrition - Obesity

• Registration Number: ACTRN12613000059763
• Lead Sponsor: Victoria University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

Participants will be considered relatively healthy males with the FTO rs9939609 risk allele (A) or two FTO rs9939609 wild type alleles (TT). Participants will be included if they have adequate glucose handling (no diagnosed diabetes, fasting blood glucose must be less than 7.0 mmol/L), not performing any regular fitness training (i.e. greater than 30 minutes, 3 times per week) for the past 6 months, not taking contraindicated prescription medication (i.e. thyroid, hyperlipidmeic, hypoglycemic, or antihypertensive), do have physician approval (if BMI over 25kg.m-2), and not current involvement in other research studies.

Exclusion Criteria

Participants will be excluded from participating within the project for the following reasons: diagnosed diabetes (fasting blood glucose greater than 7.0 mmol/L or HbA1ctest greater than 6.5%), performing any regular fitness training (i.e. greater than 30 minutes, 3 times per week) for the past 6 months, taking contraindicated prescription medication (i.e. thyroid, hyperlipidmeic, hypoglycemic, or antihypertensive), no physician approval (if BMI over 25kg.m-2), and current involvement in other research studies.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To understand whether genetic variants of the FTO gene influence the skeletal muscle’s ability to utilise carbohydrates, proteins and fats at a genetic and tissue level in response to a 12 week high intensity intermittent exercise training intervention.[Timepoints to be assessed will be the same for all 4 testing sessions (2 exercise testing sessions conducted before the intervention, and 2 exercise testing sessions after the intervention). The timepoints are at baseline/prior to exercise testing (DNA, serum & muscle), every 10 minutes during exercise (serum), immediately following exercise (serum), 15 minutes following exercise (serum & muscle), and 3 hours following exercise (serum & muscle).]

Secondary Outcome Measures

Name	Time	Method
il[Nil]