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Clinical Trials/NCT05937074
NCT05937074Active, not recruitingNot Applicable

Metabolic Response to Food in Lung Cancer

Pennington Biomedical Research Center1 site in 1 country5 target enrollmentStarted: July 18, 2023Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Active, not recruiting
Enrollment
5
Locations
1
Primary Endpoint
Respiratory quotient
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This goal of this study is to describe how unintentional weight loss influences fasting and post-prandial metabolic flexibility in participants with advanced non-small cell lung cancer.

Study Design

Study Type
Observational
Observational Model
Case Only
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age greater than or equal to 18 years
  • •Diagnosis of non-small-cell lung cancer
  • •Reported weight stability or loss after cancer diagnosis
  • •Body mass index less than or equal to 35 kilograms per meter squared
  • •Ability to provide written informed consent
  • •Willing and able to comply with all scheduled visits, treatment plans, lab tests, and other study procedure
  • •Allow the collection and storage of biospecimens and data for future use

Exclusion Criteria

  • •Prior diagnosis of diabetes mellitus (type 1 or type 2)
  • •Currently pregnant or breastfeeding
  • •Contraindication to consuming the liquid mixed meal
  • •Any medications affecting gastric motility
  • •Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol

Outcomes

Primary Outcomes

Respiratory quotient

Time Frame: Difference between pre- to post-prandial conditions over four hours

The respiratory quotient will be measured by indirect calorimetry before and after consumption of a liquid mixed meal

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Justin Brown

Director, Cancer Metabolism Program

Pennington Biomedical Research Center

Study Sites (1)

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