Qualitative somatosensory clinical evaluation of recipient and donor sites of subepithelial connective tissue Grafts

Not Applicable

• Conditions: Gingival Recession; C07.465.714.258

• Registration Number: RBR-7zz3b6p
• Lead Sponsor: niversidade de São Paulo

Brief Summary

This study aimed to qualitatively evaluate the somatosensory profile of areas that received subepithelial connective tissue graft and palatal donor areas. The subepithelial connective tissue graft plus coronal advanced flap is considered the gold standard procedure for root coverage. This technique is commonly evaluated by clinical parameters, but patient-centered outcomes and potential sensory changes need to be further explored. Therefore, sensory tests were applied at subepithelial connective tissue graft recipient and donor sites at baseline and after 3 and 6 months. A single calibrated evaluator applied the Douleur Neuropathique 4 questionnaire (DN4), the qualitative sensory test (QualST), discriminating the areas as hypersensitive, hyposensitive or normosensitive, and the two-point acuity test. Descriptive statistics, non-parametric Kruskal Wallis test for qualitative sensory test evaluation and ANOVA for the analysis of the Two-point test (p<0.05) were used. The qualitative sensory test revealed that recipient areas presented no significant differences in the tactile, pressure and thermal tests. The brush test revealed hyposensitivity after 3 months (p=0.03). In the donor areas, only the thermal evaluation showed a significant difference between baseline and after 3 and 6 months (p=0.01), being hypersensitive after 3 months and hyposensitive after 6 months. At baseline, all evaluations in recipient and donor areas were normosensitive. According to Douleur Neuropathique 4 questionnaire, no patient reported pain in recipient and donor sites. However, when a non-painful sensory perception was reported, it was numbness in the recipient (3.14% of patients) and donor (18.4%) areas. No significant differences were found for two-point acuity test values. The extent to which these alterations in sensations affected oral functions showed no impairment. This prospective study concluded that, although some punctual somatosensory changes occurred, they did not disable important oral functions, thus reinforcing the positive results obtained with periodontal plastic surgeries

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-12-15
• Study Start: 2024-01-12
• Last Update Posted: 23 January 2024

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients of both genders; age between 18 - 70 years; normal and healthy palatal area; multiple gingival recessions (RT1) with at least one gingival recession = 2 mm, including canines and premolars; systemically healthy patients with no contraindication to periodontal surgical procedures

Exclusion Criteria

Patients with prostheses with palatal coverage; palatal areas previously submitted to graft removal; teeth Mobility; smokers; pregnant and lactating women; history of periodontal disease or recurrent abscess formation; previously root coverage surgical procedures; use of medications (anticonvulsants, antihypertensives, contraceptives, or immunosuppressants) or drugs that influence wound healing; and a low level of oral hygiene (plaque index and bleeding index >20%)

Study & Design

• Study Type: Intervention
• Study Design: Not specified