Evaluation of Hepatic Fibrosis on Multiparametric MRI
- Conditions
- CirrhosisHepatitis
- Registration Number
- NCT03085342
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 49
- chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...)
- Or transplant recipient for viral hepatitis and on anti-viral agent medication
- AND scheduled for liver resection, biopsy or transient elastography
- AND signed informed consent
- younger than 18 years
- any contra-indication for contrast-enhanced MRI
- pregnant or nursing women
- biliary obstruction
- unable or unwilling to give informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method hepatic fibrosis stage 1 month after MRI F0-1 vs. F2-4 using multiparametric MRI
- Secondary Outcome Measures
Name Time Method presence of varix 1 month after MRI presence of esophageal or gastric varices using multiparametric MRI
comparison of portal flow measurement 1 month after MRI comparison of portal flow measurement using DCE and precontrast flow measurement
Related Research Topics
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Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of