NCT03085342Unknown不适用
Evaluation of Hepatic Fibrosis on Multiparametric MRI Including Portal Flow Measurement Using Dual-input Software: Preliminary Study
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- hepatic fibrosis stage
研究概览
简要总结
As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...)
- •Or transplant recipient for viral hepatitis and on anti-viral agent medication
- •AND scheduled for liver resection, biopsy or transient elastography
- •AND signed informed consent
排除标准
- •younger than 18 years
- •any contra-indication for contrast-enhanced MRI
- •pregnant or nursing women
- •biliary obstruction
- •unable or unwilling to give informed consent
结局指标
主要结局
hepatic fibrosis stage
时间窗: 1 month after MRI
F0-1 vs. F2-4 using multiparametric MRI
次要结局
- presence of varix(1 month after MRI)
- comparison of portal flow measurement(1 month after MRI)
研究者
Jeong Min Lee
Professor
Seoul National University Hospital
研究点 (1)
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