Hepatic Fibrosis Assessment Using Multiparametric Magnetic Resonance Imaging (MRI)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis
Study Overview
Brief Summary
The purpose of this study is to assess degree of hepatic fibrosis using multiparametric MRI for investigating difference between normal or early fibrosis and advanced fibrosis.
Detailed Description
In patients with liver parenchymal disease or normal liver parenchyma who are scheduled to undergo either liver resection or liver biopsy are included.
Referred patients undergo multiparametric MRI including perfusion, diffusion, elastography and fat quantification before surgery or biopsy.
The pathophysiologic changes are evaluated using multiparametric MRI, and compared between normal/early fibrosis and advanced fibrosis.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients who are scheduled to undergo liver resection for focal liver lesion
- •patients who are scheduled to undergo liver resection or percutaneous biopsy for diffuse parenchymal disease
- •liver donor candidate who are scheduled to undergo preoperative liver biopsy or liver resection
- •AND patients/living donor candidates who sign informed consent
Exclusion Criteria
- •Patients who have at least one of followings are excluded.
- •Patients who are contraindication for MRI contrast enhanced MRI.
- •Premenopausal female patients who are pregnant.
- •Patients who are physically compromised to acquire liver MRI
Outcomes
Primary Outcomes
difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis
Time Frame: in three years
Secondary Outcomes
- difference of arterial flow between no or early hepatic fibrosis and advanced hepatic fibrosis(in three years)
- difference of liver stiffness value between no or early hepatic fibrosis and advanced fibrosis(in three years)
- monitoring of transient dyspnea after contrast media injection(in three years)
Investigators
Jeong Min Lee
Professor
Seoul National University Hospital