Hepatic Fibrosis Assessment Using Multiparametric Magnetic Resonance Imaging (MRI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis
研究概览
简要总结
The purpose of this study is to assess degree of hepatic fibrosis using multiparametric MRI for investigating difference between normal or early fibrosis and advanced fibrosis.
详细描述
In patients with liver parenchymal disease or normal liver parenchyma who are scheduled to undergo either liver resection or liver biopsy are included.
Referred patients undergo multiparametric MRI including perfusion, diffusion, elastography and fat quantification before surgery or biopsy.
The pathophysiologic changes are evaluated using multiparametric MRI, and compared between normal/early fibrosis and advanced fibrosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who are scheduled to undergo liver resection for focal liver lesion
- •patients who are scheduled to undergo liver resection or percutaneous biopsy for diffuse parenchymal disease
- •liver donor candidate who are scheduled to undergo preoperative liver biopsy or liver resection
- •AND patients/living donor candidates who sign informed consent
排除标准
- •Patients who have at least one of followings are excluded.
- •Patients who are contraindication for MRI contrast enhanced MRI.
- •Premenopausal female patients who are pregnant.
- •Patients who are physically compromised to acquire liver MRI
结局指标
主要结局
difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis
时间窗: in three years
次要结局
- difference of arterial flow between no or early hepatic fibrosis and advanced hepatic fibrosis(in three years)
- difference of liver stiffness value between no or early hepatic fibrosis and advanced fibrosis(in three years)
- monitoring of transient dyspnea after contrast media injection(in three years)
研究者
Jeong Min Lee
Professor
Seoul National University Hospital