To explore the clinical, demographic profile and outcomes of patients presenting with herbicide poisoning in a tertiary care hospital

Our study title is To explore the clinical, demographic profile and outcomes of patients presenting with herbicide poisoning in a tertiary care hospital. The objectives of the study include to study the clinico-demographic profile and outcome of patients presenting with herbicide poisoning to a tertiary care hospital, to determine the factors affecting outcome (ventilator requirement, length of ICU stay, vasopressor requirement, mortality) in patients presenting with paraquat consumption, To determine the factors affecting outcome (ventilator requirement, length of ICU stay, vasopressor requirement, mortality) in patients presenting with glyphosate consumption. We will also compare scoring systems (SOFA, APACHE II, SAPS III) in predicting mortality in patients with herbicide poisoning. We will also determine the accuracy of ultrasound based composite score (Lung Ultrasound, Renal Resistive Index, Respiratory Rate) to predict 48hrs mortality in paraquat poisoning. Approval from Institutional ethics and CTRI will be taken. After the approval, patients will be enrolled as per inclusion and exclusion criteria mentioned earlier. An information sheet containing the details of the study will be given and the subjects will be explained about the objectives of the study. Informed consent will be taken from the subjects. Both information sheet and informed consent will be made available in English as well as in Kannada. Demographic details, clinical history, general and systemic examination findings will be noted.  Laboratory investigations which are sent as per treating physician will be recorded in a predesigned proforma. Ultrasound findings performed by the emergency physician/ critical care physician will be noted for the lung ultrasound score and renal resistive index. Treatment done during the course of hospital stay will be noted. 48hour mortality will be recorded. Patient outcomes will be noted- discharge/death/discharged against advice, length of hospital stays, requirement of ventilator, vasopressors and need for hemodialysis/hemoperfusion. The collected data will undergo statistical analysis.