Orofacial Pain in Multiple Sclerosis
- Conditions
- Multiple Sclerosis
- Interventions
- Diagnostic Test: Diagnosis of pain
- Registration Number
- NCT06021561
- Lead Sponsor
- Varazdin General Hospital
- Brief Summary
Although the orofacial pain is not typical symptom of multiple sclerosis, more than 50% of the patients experience some kind of pain. Acute pain usually in form of trigeminal neuralgia, that occurred in 2-3% of patients with multiple sclerosis. Chronic pain occurred in 40-50% of patients and most common forms are headache. Aim of this study is to investigate prevalence and evaluate the form of orofacial pain in patients with multiple sclerosis treated in General hospital Varaždin in period from 01.01. 2017. to 31.12.2022. Results of this investigation will determine better understanding orofacial pain , treatment and impact on everyday life.
- Detailed Description
Multiple sclerosis is a chronic autoimmune disease with an unknown mechanism of origin. Although pain is not a typical symptom of multiple sclerosis, it occurs in more than 50% of patients and has significant impact on the quality of life of patients. Pain syndromes that patients with multiple sclerosis initially have characteristics of somatic and nociceptive pain, and later neuropathic, including trigeminal neuralgia, headaches, Lhermitte's syndrome.
Pain is also often associated with anxiety and depression, which occurs in almost one third of patients.
Pain therapy in these patients is a challenge for many doctors involved in the treatment. Many patients do not have adequate pain therapy due to the disproportion between the fear of interaction with other drugs and side effects, and on the other hand the treatment of basic diseases with the aim of controlling the immune response.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- multiple scerosis
- age 18-85 years
- records with missing data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Multiple sclerosis group Diagnosis of pain Multiple sclerosis patients registered in Varazdin General Hospital from 1 January 2017 - 31 December 2022
- Primary Outcome Measures
Name Time Method The frequency of orofacial pain in patients with multiple sclerosis 3 months To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the frequency of orofacial pain (expressed in number and proportion of all patients)
The location of orofacial pain in patients with multiple sclerosis 3 months To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the loacation of orofacial pain
The duration of orofacial pain in patients with multiple sclerosis 3 months To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the duration of orofacial pain (in months)
- Secondary Outcome Measures
Name Time Method MS orofacial pain and the duration of the disease 3 months To investigate the connection between orofacial pain and the duration of the disease
Pain and daily functioning 3 months To investigate the impact of pain on the daily functioning of patients with multiple sclerosis
Pain and patients' characteristics 3 months To investigate the pain characteristics in relation to age, sex, form of the disease
Other chronic diseases and orofacial pain 3 months To investigate the influence of other chronic diseases on orofacial pain in patients with multiple sclerosis
MS therapy's influence to pain 3 months To investigate connection between orofacial pain and multiple sclerosis therapy
Trial Locations
- Locations (1)
Varazdin General Hospital
🇭🇷Varaždin, Croatia