EMOTION & COGNITION in MYOCLONUS DYSTONIA (AGENT10-ECODYST)
- Conditions
- DYT11Myoclonus-Dystonia
- Registration Number
- NCT05671068
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
Background:
Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.
Objective:
To investigate the neural correlates of cognition and emotion in DYT-SGCE.
Design:
Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.
Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.
Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.
- Detailed Description
Eligibility:
DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 40
For all participants:
- Age between 15-60 years
- Able to give informed consent.
For patients:
- An established diagnostic of DYT-SGCE
- No change in medication (related to DYT-SGCE) for a month
For controls:
- No neurological symptoms
- No medication except oral contraception
- No deprivation of liberty
- Inability to give a consent
- Established cognitive alteration
- Contraindication to MRI (per MRI safety checklist)
- Severe chronic psychiatric illness
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BOLD signal derived from the functional magnetic resonance imaging 46 month Explore the differences in DYT-SGCE compared to HV
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brain Institute
🇫🇷Paris, France