The Relationship Between Left Atrial Pressure and Cardiac Function After Atrioventricular Node Ablation

Not Applicable

Completed

• Conditions: Atrial Fibrillation
• Interventions: Procedure: left atrial pressure regulation

• Registration Number: NCT05449158
• Lead Sponsor: Shanghai 10th People's Hospital

Brief Summary

Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing

Detailed Description

Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing. For patients with non-valvular atrial fibrillation who received atrioventricular node ablation combined with left bundle branch pacing in our hospital, a left atrial pressure catheter was used to monitor atrial pressure during the operation, and a lower average atrial pressure was obtained by adjusting the pacing frequency of the pacemaker. In a randomized controlled manner, the postoperative echocardiography, cardiothoracic ratio, cardiac function, etc. were compared between patients without atrial pressure monitoring and those who received atrial pressure adjustment, in order to clarify the effect of left atrial pressure-guided ventricular rate adjustment on atrioventricular node ablation combined with left bundle Benefit of pacing patients.

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2022-05-01
• Study Completion: 2022-06-28
• Study First Submitted: 2022-06-28
• Status Verified: 2022-07
• Study First Submitted QC: 2022-07-07
• Last Update Submitted: 2022-07-07
• Study First Posted: 2022-07-08
• Last Update Posted: 2022-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

18-85 years old atrial fibrillation patients

Exclusion Criteria

There is a history of pacemaker implantation; patients after coronary artery bypass grafting; severe coronary stenosis or occlusion cannot be treated with reperfusion;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LAP Group	left atrial pressure regulation	Control of left atrial pressure changes by adjusting pacemaker frequency

Primary Outcome Measures

Name	Time	Method
EF%	1-year	aortic vestibular ejection fraction

Secondary Outcome Measures

Name	Time	Method
Hospitalizations for heart failure	1 years	Hospitalizations for heart failure
cardiovascular all-cause mortality	1week	Proportion of patients dying from cardiovascular causes

Trial Locations

Locations (1)

Jun Zhang; 🇨🇳 Shanghai, Shanghai, China