LUME-Ovar 1: Nintedanib (BIBF 1120) or Placebo in Combination With Paclitaxel and Carboplatin in First Line Treatment of Ovarian Cancer
- Conditions
- Ovarian NeoplasmsPeritoneal Neoplasms
- Interventions
- Registration Number
- NCT01015118
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
The trial will be performed to evaluate if BIBF 1120 in combination with paclitaxel and carboplatin is more effective than placebo in combination with paclitaxel and carboplatin in first-line treatment of patients with advanced ovarian cancer. Safety information about BIBF1120/paclitaxel/carboplatin will be obtained.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 1366
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description BIBF 1120 BIBF 1120 patients to receive BIBF 1120 standard dose twice daily PO in combination with combination with carboplatin and paclitaxel Placebo Placebo patients to receive capsules identical to those containing BIBF 1120 in combination with combination with carboplatin and paclitaxel BIBF 1120 Paclitaxel patients to receive BIBF 1120 standard dose twice daily PO in combination with combination with carboplatin and paclitaxel BIBF 1120 Carboplatin patients to receive BIBF 1120 standard dose twice daily PO in combination with combination with carboplatin and paclitaxel Placebo Carboplatin patients to receive capsules identical to those containing BIBF 1120 in combination with combination with carboplatin and paclitaxel Placebo Paclitaxel patients to receive capsules identical to those containing BIBF 1120 in combination with combination with carboplatin and paclitaxel
- Primary Outcome Measures
Name Time Method PFS Based on Investigator Assessment According to Modified Response Evaluation Criteria in Solid Tumors, Version 1.1 (mRECIST), and Additional Clinical Criteria. First drug administration to date of disease progression or death whichever occurs first , upto 29 months Progression free survival (PFS) is calculated as the time from randomisation to the date of disease progression, or to the date of death, whichever occurs first according to the Investigator assessment.
The primary PFS analysis of this trial was performed when approximately 753 patients had experienced a PFS event
Median, 25th and 75th percentiles are calculated from an unadjusted Kaplan-Meier curve for each treatment arm.PFS Based on Investigator Assessment According to Modified Response Evaluation Criteria in Solid Tumors, Version 1.1 (mRECIST), and Additional Clinical Criteria (Follow up Analysis). First drug administration to date of disease progression or death whichever occurs first until final Data Base Lock (DBL) 26September16, upto 62 months Follow-up analysis was conducted at the time of overall survival analysis. Progression free survival (PFS) is calculated as the time from randomisation to the date of disease progression, or to the date of death, whichever occurs first according to the Investigator assessment.
Median, 25th and 75th percentiles are calculated from an unadjusted Kaplan-Meier curve for each treatment arm.
- Secondary Outcome Measures
Name Time Method PFS Based on Investigator Assessment According to mRECIST Version 1.1 (Key Secondary Endpoint - Follow up Analysis). First drug administration to date of disease progression or death whichever occurs first until final Data Base Lock (DBL) 26September16, upto 62 months Follow-up analysis was conducted at the time of overall survival analysis. Progression free survival is calculated as the time from randomisation to the date of disease progression, or to the date of death, whichever occurs first based on the Investigator assessment according to Modified Response Evaluation Criteria (mRECIST), version 1.1. Median, 25th and 75th percentiles are calculated from an unadjusted Kaplan-Meier curve for each treatment arm.
Time to CA-125 Tumour Marker Progression First drug administration until final DBL 26September16, upto 62 months Time to tumour-marker progression was defined as the time from randomisation until the date when Carbohydrate (cancer) antigen (CA-125) values increased to higher than twice the nadir value. CA-125 \>=2 x nadir in case nadir value \> Upper limit of normal (ULN) or CA-125 \>=2 x ULN in case nadir value \<= ULN.
Objective Response Based on Investigator Assessment First drug administration until final DBL 26September16, upto 62 months Objective tumour response defined as either complete response \[CR\] or partial response \[PR\] in patients with at least 1 target lesion reported at baseline
Change in Abdominal/Gastro-intestinal Symptoms Over Time First drug administration until final DBL 26September16, upto 62 months Change in abdominal/gastro-intestinal over time was calculated on symptoms (scale composite of items 31 to 37 of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Module for Ovarian Cancer 28 (EORTC QLQ OV-28).
As specified in the EORTC scoring manual, for each scale or item, a linear transformation was applied to standardize the raw score to a range from 0 to 100 (high scores represent a high/severe level of symptomatology).
Mean presented is Adjusted mean. Adjusted for the stratification factors macroscopic residual postoperative tumour at baseline (yes vs. no), FIGO stage (IIB-III vs IV), and Carboplatin level (AUC5 vs. AUC6).PFS Based on Investigator Assessment According to mRECIST Version 1.1 (Key Secondary Endpoint). First drug administration to date of disease progression or death whichever occurs first , upto 29 months Progression free survival is calculated as the time from randomisation to the date of disease progression, or to the date of death, whichever occurs first based on the Investigator assessment according to Modified Response Evaluation Criteria (mRECIST), version 1.1.
The primary PFS analysis of this trial was performed when approximately 753 patients had experienced a PFS event.
Median, 25th and 75th percentiles are calculated from an unadjusted Kaplan-Meier curve for each treatment arm.Overall Survival First drug administration to date of death until final DBL 26September16, upto 62 months Overall survival is defined as time from randomization to date of death (irrespective of reason).
Median, 25th and 75th percentiles are calculated from an unadjusted Kaplan-Meier curve for each treatment arm.Change in Global Health Status/ Quality of Life (QoL) Scale Over Time. First drug administration until final DBL 26September16, upto 62 months Change in Global Health Status/ Quality of life (QoL) over time was calculated on Global Health Status/QoL scale (composite of items 29 and 30 of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30) as a general measure.
As specified in the EORTC scoring manual, for each scale or item, a linear transformation was applied to standardize the raw score to a range from 0 to 100 (high scores represent a high/healthy level of functioning).
Mean presented is Adjusted mean. Adjusted for the stratification factors macroscopic residual postoperative tumour at baseline (yes vs. no), FIGO stage (IIB-III vs IV), and Carboplatin level (AUC5 vs. AUC6).
Trial Locations
- Locations (281)
1199.15.10019 Boehringer Ingelheim Investigational Site
🇺🇸Bismarck, North Dakota, United States
1199.15.10024 Boehringer Ingelheim Investigational Site
🇺🇸Canton, Ohio, United States
1199.15.10107 Boehringer Ingelheim Investigational Site
🇺🇸Dallas, Texas, United States
1199.15.10006 Boehringer Ingelheim Investigational Site
🇺🇸Chattanooga, Tennessee, United States
1199.15.10108 Boehringer Ingelheim Investigational Site
🇺🇸Dallas, Texas, United States
1199.15.61006 Boehringer Ingelheim Investigational Site
🇦🇺Camperdown, New South Wales, Australia
1199.15.11009 Boehringer Ingelheim Investigational Site
🇨🇦Toronto, Ontario, Canada
1199.15.10029 Boehringer Ingelheim Investigational Site
🇺🇸Cleveland, Ohio, United States
1199.15.10007 Boehringer Ingelheim Investigational Site
🇺🇸Houston, Texas, United States
1199.15.38002 Boehringer Ingelheim Investigational Site
🇺🇦Kharkiv, Ukraine
1199.15.43013 Boehringer Ingelheim Investigational Site
🇦🇹Wels, Austria
1199.15.35104 Boehringer Ingelheim Investigational Site
🇵🇹Coimbra, Portugal
1199.15.43012 Boehringer Ingelheim Investigational Site
🇦🇹Wien, Austria
1199.15.35804 Boehringer Ingelheim Investigational Site
🇫🇮Jyväskylä, Finland
1199.15.35803 Boehringer Ingelheim Investigational Site
🇫🇮Oulu, Finland
1199.15.11005 Boehringer Ingelheim Investigational Site
🇨🇦Vancouver, British Columbia, Canada
1199.15.43002 Boehringer Ingelheim Investigational Site
🇦🇹Wien, Austria
1199.15.35801 Boehringer Ingelheim Investigational Site
🇫🇮Helsinki, Finland
1199.15.43003 Boehringer Ingelheim Investigational Site
🇦🇹Graz, Austria
1199.15.43011 Boehringer Ingelheim Investigational Site
🇦🇹Krems, Austria
1199.15.35805 Boehringer Ingelheim Investigational Site
🇫🇮Kuopio, Finland
1199.15.35802 Boehringer Ingelheim Investigational Site
🇫🇮Tampere, Finland
1199.15.35109 Boehringer Ingelheim Investigational Site
🇵🇹Vila Real, Portugal
1199.15.47004 Boehringer Ingelheim Investigational Site
🇳🇴Trondheim, Norway
1199.15.35102 Boehringer Ingelheim Investigational Site
🇵🇹Coimbra, Portugal
1199.15.42102 Boehringer Ingelheim Investigational Site
🇸🇰Zilina, Slovakia
1199.15.42103 Boehringer Ingelheim Investigational Site
🇸🇰Nitra, Slovakia
1199.15.39039 Boehringer Ingelheim Investigational Site
🇮🇹Ferrara, Italy
1199.15.39017 Boehringer Ingelheim Investigational Site
🇮🇹Genova, Italy
1199.15.39011 Boehringer Ingelheim Investigational Site
🇮🇹Palermo, Italy
1199.15.33051 Boehringer Ingelheim Investigational Site
🇫🇷PERIGUEUX Cedex, France
1199.15.33030 Boehringer Ingelheim Investigational Site
🇫🇷Plerin SUR MER, France
1199.15.33033 Boehringer Ingelheim Investigational Site
🇫🇷Saint-Herblain cedex, France
1199.15.33018 Boehringer Ingelheim Investigational Site
🇫🇷Strasbourg cedex, France
1199.15.33039 Boehringer Ingelheim Investigational Site
🇫🇷Thonon-Les-Bains, France
1199.15.33031 Boehringer Ingelheim Investigational Site
🇫🇷Vandoeuvre les Nancy cedex, France
1199.15.44005 Boehringer Ingelheim Investigational Site
🇬🇧London, United Kingdom
1199.15.11001 Boehringer Ingelheim Investigational Site
🇨🇦Sherbrooke, Quebec, Canada
1199.15.11006 Boehringer Ingelheim Investigational Site
🇨🇦Montreal, Quebec, Canada
1199.15.10001 Boehringer Ingelheim Investigational Site
🇺🇸Santa Rosa, California, United States
1199.15.10113 Boehringer Ingelheim Investigational Site
🇺🇸Tucson, Arizona, United States
1199.15.10010 Boehringer Ingelheim Investigational Site
🇺🇸Augusta, Georgia, United States
1199.15.10030 Boehringer Ingelheim Investigational Site
🇺🇸Long Beach, California, United States
1199.15.43001 Boehringer Ingelheim Investigational Site
🇦🇹Innsbruck, Austria
1199.15.10005 Boehringer Ingelheim Investigational Site
🇺🇸Englewood, Colorado, United States
1199.15.45001 Boehringer Ingelheim Investigational Site
🇩🇰Købenahvn Ø, Denmark
1199.15.42003 Boehringer Ingelheim Investigational Site
🇨🇿Olomouc, Czechia
1199.15.10017 Boehringer Ingelheim Investigational Site
🇺🇸Detroit, Michigan, United States
1199.15.33006 Boehringer Ingelheim Investigational Site
🇫🇷Caen cedex 5, France
1199.15.45003 Boehringer Ingelheim Investigational Site
🇩🇰Odense C, Denmark
1199.15.10011 Boehringer Ingelheim Investigational Site
🇺🇸Louisville, Kentucky, United States
1199.15.10016 Boehringer Ingelheim Investigational Site
🇺🇸Allentown, Pennsylvania, United States
1199.15.61004 Boehringer Ingelheim Investigational Site
🇦🇺Herston, Queensland, Australia
1199.15.61005 Boehringer Ingelheim Investigational Site
🇦🇺North Terrace, South Australia, Australia
1199.15.61002 Boehringer Ingelheim Investigational Site
🇦🇺Nedlands, Western Australia, Australia
1199.15.61007 Boehringer Ingelheim Investigational Site
🇦🇺Parkville, Victoria, Australia
1199.15.43005 Boehringer Ingelheim Investigational Site
🇦🇹Linz, Austria
1199.15.33021 Boehringer Ingelheim Investigational Site
🇫🇷Monaco Cedex, France
1199.15.33053 Boehringer Ingelheim Investigational Site
🇫🇷Mougins, France
1199.15.45004 Boehringer Ingelheim Investigational Site
🇩🇰Aalborg, Denmark
1199.15.42001 Boehringer Ingelheim Investigational Site
🇨🇿Prague, Czechia
1199.15.33001 Boehringer Ingelheim Investigational Site
🇫🇷Paris, France
1199.15.49086 Boehringer Ingelheim Investigational Site
🇩🇪Aschaffenburg, Germany
1199.15.33042 Boehringer Ingelheim Investigational Site
🇫🇷Fréjus, France
1199.15.49070 Boehringer Ingelheim Investigational Site
🇩🇪Aalen, Germany
1199.15.49046 Boehringer Ingelheim Investigational Site
🇩🇪Fulda, Germany
1199.15.33011 Boehringer Ingelheim Investigational Site
🇫🇷Marseille cedex 09, France
1199.15.33008 Boehringer Ingelheim Investigational Site
🇫🇷Le Mans, France
1199.15.49043 Boehringer Ingelheim Investigational Site
🇩🇪Chemnitz, Germany
1199.15.49066 Boehringer Ingelheim Investigational Site
🇩🇪Essen, Germany
1199.15.49040 Boehringer Ingelheim Investigational Site
🇩🇪Aachen, Germany
1199.15.33045 Boehringer Ingelheim Investigational Site
🇫🇷Saint Cloud, France
1199.15.33052 Boehringer Ingelheim Investigational Site
🇫🇷Montpellier cedex 5, France
1199.15.33038 Boehringer Ingelheim Investigational Site
🇫🇷Nancy, France
1199.15.49008 Boehringer Ingelheim Investigational Site
🇩🇪Düsseldorf, Germany
1199.15.49081 Boehringer Ingelheim Investigational Site
🇩🇪Böblingen, Germany
1199.15.49004 Boehringer Ingelheim Investigational Site
🇩🇪Bonn, Germany
1199.15.49011 Boehringer Ingelheim Investigational Site
🇩🇪Freiburg, Germany
1199.15.49068 Boehringer Ingelheim Investigational Site
🇩🇪Freiburg, Germany
1199.15.49012 Boehringer Ingelheim Investigational Site
🇩🇪Fürstenfeldbruck, Germany
1199.15.49014 Boehringer Ingelheim Investigational Site
🇩🇪Halle/S., Germany
1199.15.49048 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
1199.15.30003 Boehringer Ingelheim Investigational Site
🇬🇷Heraklio, Greece
1199.15.39036 Boehringer Ingelheim Investigational Site
🇮🇹Milano, Italy
1199.15.39010 Boehringer Ingelheim Investigational Site
🇮🇹Modena, Italy
1199.15.39018 Boehringer Ingelheim Investigational Site
🇮🇹Sondrio, Italy
1199.15.39006 Boehringer Ingelheim Investigational Site
🇮🇹Tappino (CB), Italy
1199.15.49082 Boehringer Ingelheim Investigational Site
🇩🇪Paderborn, Germany
1199.15.47001 Boehringer Ingelheim Investigational Site
🇳🇴Oslo, Norway
1199.15.35106 Boehringer Ingelheim Investigational Site
🇵🇹Lisboa, Portugal
1199.15.39031 Boehringer Ingelheim Investigational Site
🇮🇹Palermo, Italy
1199.15.35108 Boehringer Ingelheim Investigational Site
🇵🇹Lisboa, Portugal
1199.15.39024 Boehringer Ingelheim Investigational Site
🇮🇹Reggio Emilia, Italy
1199.15.39030 Boehringer Ingelheim Investigational Site
🇮🇹San Fermo Della Battaglia, Italy
1199.15.49050 Boehringer Ingelheim Investigational Site
🇩🇪Regensburg, Germany
1199.15.39008 Boehringer Ingelheim Investigational Site
🇮🇹Faenza (RA), Italy
1199.15.39028 Boehringer Ingelheim Investigational Site
🇮🇹Milano, Italy
1199.15.39012 Boehringer Ingelheim Investigational Site
🇮🇹Pordenone, Italy
1199.15.39029 Boehringer Ingelheim Investigational Site
🇮🇹Brescia, Italy
1199.15.39040 Boehringer Ingelheim Investigational Site
🇮🇹Catania, Italy
1199.15.39007 Boehringer Ingelheim Investigational Site
🇮🇹Catanzaro, Italy
1199.15.49056 Boehringer Ingelheim Investigational Site
🇩🇪Stuttgart, Germany
1199.15.49090 Boehringer Ingelheim Investigational Site
🇩🇪Stuttgart, Germany
1199.15.39019 Boehringer Ingelheim Investigational Site
🇮🇹Torino, Italy
1199.15.39020 Boehringer Ingelheim Investigational Site
🇮🇹Torino, Italy
1199.15.39013 Boehringer Ingelheim Investigational Site
🇮🇹Roma, Italy
1199.15.31004 Boehringer Ingelheim Investigational Site
🇳🇱Niewegein, Netherlands
1199.15.39001 Boehringer Ingelheim Investigational Site
🇮🇹Napoli, Italy
1199.15.31002 Boehringer Ingelheim Investigational Site
🇳🇱Utrecht, Netherlands
1199.15.35105 Boehringer Ingelheim Investigational Site
🇵🇹Porto, Portugal
1199.15.31009 Boehringer Ingelheim Investigational Site
🇳🇱's-HERTOGENBOSCH, Netherlands
1199.15.46003 Boehringer Ingelheim Investigational Site
🇸🇪Uppsala, Sweden
1199.15.47003 Boehringer Ingelheim Investigational Site
🇳🇴Bergen, Norway
1199.15.35101 Instituto Portugues de Oncologia Lisboa Francisco Gentil
🇵🇹Lisboa, Portugal
1199.15.48006 Boehringer Ingelheim Investigational Site
🇵🇱Lublin, Poland
1199.15.70005 Boehringer Ingelheim Investigational Site
🇷🇺Ekaterinburg, Russian Federation
1199.15.70006 Boehringer Ingelheim Investigational Site
🇷🇺Barnaul, Russian Federation
1199.15.44004 Boehringer Ingelheim Investigational Site
🇬🇧Nottingham, United Kingdom
1199.15.42104 Boehringer Ingelheim Investigational Site
🇸🇰Poprad, Slovakia
1199.15.38005 Boehringer Ingelheim Investigational Site
🇺🇦Dnepropetrovsk, Ukraine
1199.15.38004 Boehringer Ingelheim Investigational Site
🇺🇦Donetsk, Ukraine
1199.15.44002 Boehringer Ingelheim Investigational Site
🇬🇧Poole, United Kingdom
1199.15.44001 Boehringer Ingelheim Investigational Site
🇬🇧Guildford, United Kingdom
1199.15.42105 Boehringer Ingelheim Investigational Site
🇸🇰Bratislava, Slovakia
1199.15.70001 Boehringer Ingelheim Investigational Site
🇷🇺Moscow, Russian Federation
1199.15.42101 Boehringer Ingelheim Investigational Site
🇸🇰Bratislava, Slovakia
1199.15.34003 Boehringer Ingelheim Investigational Site
🇪🇸Barcelona, Spain
1199.15.44006 Boehringer Ingelheim Investigational Site
🇬🇧Derby, United Kingdom
1199.15.44007 Boehringer Ingelheim Investigational Site
🇬🇧Dundee, United Kingdom
1199.15.44003 Boehringer Ingelheim Investigational Site
🇬🇧Glasgow, United Kingdom
1199.15.70007 Boehringer Ingelheim Investigational Site
🇷🇺Kazan, Russian Federation
1199.15.49002 Boehringer Ingelheim Investigational Site
🇩🇪Berlin, Germany
1199.15.49042 Boehringer Ingelheim Investigational Site
🇩🇪Bonn, Germany
1199.15.49071 Boehringer Ingelheim Investigational Site
🇩🇪Bottrop, Germany
1199.15.49005 Boehringer Ingelheim Investigational Site
🇩🇪Dessau, Germany
1199.15.49024 Boehringer Ingelheim Investigational Site
🇩🇪Marburg, Germany
1199.15.49095 Boehringer Ingelheim Investigational Site
🇩🇪Heidelberg, Germany
1199.15.49017 Boehringer Ingelheim Investigational Site
🇩🇪Kiel, Germany
1199.15.49019 Boehringer Ingelheim Investigational Site
🇩🇪Lübeck, Germany
1199.15.49027 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
1199.15.49065 Boehringer Ingelheim Investigational Site
🇩🇪Neumarkt i.d.Opf., Germany
1199.15.49061 Boehringer Ingelheim Investigational Site
🇩🇪Ravensburg, Germany
1199.15.49051 Boehringer Ingelheim Investigational Site
🇩🇪Rosenheim, Germany
1199.15.49054 Boehringer Ingelheim Investigational Site
🇩🇪Saalfeld, Germany
1199.15.49058 Boehringer Ingelheim Investigational Site
🇩🇪Ulm, Germany
1199.15.49085 Boehringer Ingelheim Investigational Site
🇩🇪Viersen, Germany
1199.15.49036 Boehringer Ingelheim Investigational Site
🇩🇪Wiesbaden, Germany
1199.15.49037 Boehringer Ingelheim Investigational Site
🇩🇪Wolfsburg, Germany
1199.15.49060 Boehringer Ingelheim Investigational Site
🇩🇪Worms, Germany
1199.15.33050 Boehringer Ingelheim Investigational Site
🇫🇷Villejuif Cedex, France
1199.15.49029 Boehringer Ingelheim Investigational Site
🇩🇪Offenbach, Germany
1199.15.49001 Boehringer Ingelheim Investigational Site
🇩🇪Wiesbaden, Germany
1199.15.10014 Boehringer Ingelheim Investigational Site
🇺🇸Orlando, Florida, United States
1199.15.10028 Boehringer Ingelheim Investigational Site
🇺🇸New Haven, Connecticut, United States
1199.15.10103 Boehringer Ingelheim Investigational Site
🇺🇸Minneapolis, Minnesota, United States
1199.15.10003 Boehringer Ingelheim Investigational Site
🇺🇸Marrero, Louisiana, United States
1199.15.10004 Boehringer Ingelheim Investigational Site
🇺🇸Savannah, Georgia, United States
1199.15.10021 Boehringer Ingelheim Investigational Site
🇺🇸Portland, Oregon, United States
1199.15.10012 Boehringer Ingelheim Investigational Site
🇺🇸Charlotte, North Carolina, United States
1199.15.10020 Boehringer Ingelheim Investigational Site
🇺🇸Winston-Salem, North Carolina, United States
1199.15.10002 Boehringer Ingelheim Investigational Site
🇺🇸New York, New York, United States
1199.15.10025 Boehringer Ingelheim Investigational Site
🇺🇸Cleveland, Ohio, United States
1199.15.10104 Boehringer Ingelheim Investigational Site
🇺🇸Austin, Texas, United States
1199.15.10008 Boehringer Ingelheim Investigational Site
🇺🇸Providence, Rhode Island, United States
1199.15.10102 Boehringer Ingelheim Investigational Site
🇺🇸Greenville, South Carolina, United States
1199.15.10013 Boehringer Ingelheim Investigational Site
🇺🇸Abington, Pennsylvania, United States
1199.15.10100 Boehringer Ingelheim Investigational Site
🇺🇸Bedford, Texas, United States
1199.15.10105 Boehringer Ingelheim Investigational Site
🇺🇸Spokane, Washington, United States
1199.15.10110 Boehringer Ingelheim Investigational Site
🇺🇸Fort Worth, Texas, United States
1199.15.10112 Boehringer Ingelheim Investigational Site
🇺🇸Vancouver, Washington, United States
1199.15.61003 Boehringer Ingelheim Investigational Site
🇦🇺Southe Brisbane, Queensland, Australia
1199.15.61001 Boehringer Ingelheim Investigational Site
🇦🇺Waratah, New South Wales, Australia
1199.15.43007 Boehringer Ingelheim Investigational Site
🇦🇹Kufstein, Austria
1199.15.32010 Boehringer Ingelheim Investigational Site
🇧🇪Edegem, Belgium
1199.15.32012 Boehringer Ingelheim Investigational Site
🇧🇪Hasselt, Belgium
1199.15.43010 Boehringer Ingelheim Investigational Site
🇦🇹Salzburg, Austria
1199.15.32003 Boehringer Ingelheim Investigational Site
🇧🇪La Louvière, Belgium
1199.15.32007 Boehringer Ingelheim Investigational Site
🇧🇪Liège, Belgium
1199.15.32008 Boehringer Ingelheim Investigational Site
🇧🇪Sint-Niklaas, Belgium
1199.15.32001 Boehringer Ingelheim Investigational Site
🇧🇪Leuven, Belgium
1199.15.11004 Boehringer Ingelheim Investigational Site
🇨🇦Hamilton, Ontario, Canada
1199.15.11008 Boehringer Ingelheim Investigational Site
🇨🇦London, Ontario, Canada
1199.15.45002 Boehringer Ingelheim Investigational Site
🇩🇰Herlev, Denmark
1199.15.45005 Boehringer Ingelheim Investigational Site
🇩🇰Herning, Denmark
1199.15.11003 Boehringer Ingelheim Investigational Site
🇨🇦Montreal, Quebec, Canada
1199.15.42002 Boehringer Ingelheim Investigational Site
🇨🇿Brno, Czechia
1199.15.33003 Boehringer Ingelheim Investigational Site
🇫🇷Bordeaux cedex, France
1199.15.33035 Boehringer Ingelheim Investigational Site
🇫🇷Avignon cedex 02, France
1199.15.33047 Boehringer Ingelheim Investigational Site
🇫🇷Aix-en-Provence, France
1199.15.33055 Boehringer Ingelheim Investigational Site
🇫🇷Besançon, France
1199.15.33004 Boehringer Ingelheim Investigational Site
🇫🇷Bordeaux, France
1199.15.33025 Boehringer Ingelheim Investigational Site
🇫🇷Clermont-Ferrand cedex, France
1199.15.33037 Boehringer Ingelheim Investigational Site
🇫🇷La Roche-Sur-Yon cedex 09, France
1199.15.33048 Boehringer Ingelheim Investigational Site
🇫🇷Dechy, France
1199.15.33009 Boehringer Ingelheim Investigational Site
🇫🇷Lille cedex, France
1199.15.33020 Boehringer Ingelheim Investigational Site
🇫🇷Lyon, France
1199.15.33012 Boehringer Ingelheim Investigational Site
🇫🇷Mont-de-Marsan cedex, France
1199.15.33013 Boehringer Ingelheim Investigational Site
🇫🇷Nantes cedex 02, France
1199.15.33015 Boehringer Ingelheim Investigational Site
🇫🇷Orléans cedex 02, France
1199.15.33027 Boehringer Ingelheim Investigational Site
🇫🇷Paris cedex 20, France
1199.15.49039 Boehringer Ingelheim Investigational Site
🇩🇪Berlin, Germany
1199.15.49041 Boehringer Ingelheim Investigational Site
🇩🇪Berlin, Germany
1199.15.49007 Boehringer Ingelheim Investigational Site
🇩🇪Dresden, Germany
1199.15.49006 Boehringer Ingelheim Investigational Site
🇩🇪Detmold, Germany
1199.15.49067 Boehringer Ingelheim Investigational Site
🇩🇪Dresden, Germany
1199.15.49009 Boehringer Ingelheim Investigational Site
🇩🇪Ebersberg, Germany
1199.15.49045 Boehringer Ingelheim Investigational Site
🇩🇪Frankfurt, Germany
1199.15.49010 Boehringer Ingelheim Investigational Site
🇩🇪Essen, Germany
1199.15.49089 Boehringer Ingelheim Investigational Site
🇩🇪Essen, Germany
1199.15.49083 Boehringer Ingelheim Investigational Site
🇩🇪Freudenstadt, Germany
1199.15.49064 Boehringer Ingelheim Investigational Site
🇩🇪Greifswald, Germany
1199.15.49015 Boehringer Ingelheim Investigational Site
🇩🇪Hamburg, Germany
1199.15.49076 Boehringer Ingelheim Investigational Site
🇩🇪Gütersloh, Germany
1199.15.49084 Boehringer Ingelheim Investigational Site
🇩🇪Hamburg, Germany
1199.15.49080 Boehringer Ingelheim Investigational Site
🇩🇪Henstedt-Ulzburg, Germany
1199.15.49073 Boehringer Ingelheim Investigational Site
🇩🇪Hanau, Germany
1199.15.49047 Boehringer Ingelheim Investigational Site
🇩🇪Hildesheim, Germany
1199.15.49062 Boehringer Ingelheim Investigational Site
🇩🇪Krefeld, Germany
1199.15.49016 Boehringer Ingelheim Investigational Site
🇩🇪Karlsruhe, Germany
1199.15.49018 Boehringer Ingelheim Investigational Site
🇩🇪Landshut, Germany
1199.15.49087 Boehringer Ingelheim Investigational Site
🇩🇪Ludwigsburg, Germany
1199.15.49021 Boehringer Ingelheim Investigational Site
🇩🇪Mainz, Germany
1199.15.49022 Boehringer Ingelheim Investigational Site
🇩🇪Mainz, Germany
1199.15.49020 Boehringer Ingelheim Investigational Site
🇩🇪Magdeburg, Germany
1199.15.49025 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
1199.15.49026 Boehringer Ingelheim Investigational Site
🇩🇪München, Germany
1199.15.49030 Boehringer Ingelheim Investigational Site
🇩🇪Radebeul, Germany
1199.15.49023 Boehringer Ingelheim Investigational Site
🇩🇪Mannheim, Germany
1199.15.49031 Boehringer Ingelheim Investigational Site
🇩🇪Salzgitter, Germany
1199.15.49052 Boehringer Ingelheim Investigational Site
🇩🇪Rostock, Germany
1199.15.49055 Boehringer Ingelheim Investigational Site
🇩🇪Solingen, Germany
1199.15.49093 Boehringer Ingelheim Investigational Site
🇩🇪Stralsund, Germany
1199.15.49063 Boehringer Ingelheim Investigational Site
🇩🇪Stendal, Germany
1199.15.49092 Boehringer Ingelheim Investigational Site
🇩🇪Stadthagen, Germany
1199.15.49033 Boehringer Ingelheim Investigational Site
🇩🇪Stuttgart, Germany
1199.15.49034 Boehringer Ingelheim Investigational Site
🇩🇪Traunstein, Germany
1199.15.49079 Boehringer Ingelheim Investigational Site
🇩🇪Suhl, Germany
1199.15.49057 Boehringer Ingelheim Investigational Site
🇩🇪Trier, Germany
1199.15.30005 Boehringer Ingelheim Investigational Site
🇬🇷Patras, Greece
1199.15.30001 Boehringer Ingelheim Investigational Site
🇬🇷Athens, Greece
1199.15.49035 Boehringer Ingelheim Investigational Site
🇩🇪Tübingen, Germany
1199.15.49059 Boehringer Ingelheim Investigational Site
🇩🇪Witten, Germany
1199.15.30002 Boehringer Ingelheim Investigational Site
🇬🇷Nea Kifisia, Greece
1199.15.39002 Boehringer Ingelheim Investigational Site
🇮🇹Avellino, Italy
1199.15.30004 Boehringer Ingelheim Investigational Site
🇬🇷Thessaloniki, Greece
1199.15.39027 Boehringer Ingelheim Investigational Site
🇮🇹Asti, Italy
1199.15.39003 Boehringer Ingelheim Investigational Site
🇮🇹Aviano (pn), Italy
1199.15.39004 Boehringer Ingelheim Investigational Site
🇮🇹Bari, Italy
1199.15.39005 Boehringer Ingelheim Investigational Site
🇮🇹Benevento, Italy
1199.15.39037 Boehringer Ingelheim Investigational Site
🇮🇹Lecce, Italy
1199.15.39033 Boehringer Ingelheim Investigational Site
🇮🇹Meldola (fc), Italy
1199.15.39009 Boehringer Ingelheim Investigational Site
🇮🇹Mantova, Italy
1199.15.39026 Boehringer Ingelheim Investigational Site
🇮🇹Monza, Italy
1199.15.39021 Boehringer Ingelheim Investigational Site
🇮🇹Milano, Italy
1199.15.39022 Boehringer Ingelheim Investigational Site
🇮🇹Padova, Italy
1199.15.39023 Boehringer Ingelheim Investigational Site
🇮🇹Pisa, Italy
1199.15.39014 Boehringer Ingelheim Investigational Site
🇮🇹Roma, Italy
1199.15.39034 Boehringer Ingelheim Investigational Site
🇮🇹Rozzano (MI), Italy
1199.15.39032 Boehringer Ingelheim Investigational Site
🇮🇹Varese, Italy
1199.15.31005 Boehringer Ingelheim Investigational Site
🇳🇱Amersfoort, Netherlands
1199.15.31003 Boehringer Ingelheim Investigational Site
🇳🇱Nijmegen, Netherlands
1199.15.31006 Boehringer Ingelheim Investigational Site
🇳🇱Rotterdam, Netherlands
1199.15.47002 Boehringer Ingelheim Investigational Site
🇳🇴Stavanger, Norway
1199.15.48003 Boehringer Ingelheim Investigational Site
🇵🇱Gdansk, Poland
1199.15.48001 Boehringer Ingelheim Investigational Site
🇵🇱Warszawa, Poland
1199.15.70002 Boehringer Ingelheim Investigational Site
🇷🇺St. Petersburg, Russian Federation
1199.15.42106 Boehringer Ingelheim Investigational Site
🇸🇰Kosice, Slovakia
1199.15.34006 Boehringer Ingelheim Investigational Site
🇪🇸Girona, Spain
1199.15.34002 Boehringer Ingelheim Investigational Site
🇪🇸Madrid, Spain
1199.15.34004 Boehringer Ingelheim Investigational Site
🇪🇸Lleida, Spain
1199.15.34001 Boehringer Ingelheim Investigational Site
🇪🇸Badalona, Spain
1199.15.34010 Boehringer Ingelheim Investigational Site
🇪🇸Madrid, Spain
1199.15.34005 Boehringer Ingelheim Investigational Site
🇪🇸Palma de Mallorca, Spain
1199.15.34009 Boehringer Ingelheim Investigational Site
🇪🇸Valencia, Spain
1199.15.46005 Boehringer Ingelheim Investigational Site
🇸🇪Linköping, Sweden
1199.15.46001 Boehringer Ingelheim Investigational Site
🇸🇪Lund, Sweden
1199.15.38006 Boehringer Ingelheim Investigational Site
🇺🇦Cherkasy, Ukraine
1199.15.46002 Boehringer Ingelheim Investigational Site
🇸🇪Stockholm, Sweden
1199.15.46004 Boehringer Ingelheim Investigational Site
🇸🇪Umeå, Sweden
1199.15.44008 Boehringer Ingelheim Investigational Site
🇬🇧Truro, United Kingdom
1199.15.38003 Boehringer Ingelheim Investigational Site
🇺🇦Lviv, Ukraine