4beta-hydroxycholesterol in Cirrhosis
Suspended
- Conditions
- Cirrhosis, Liver
- Interventions
- Other: There is no intervention, only research blood samples are collected
- Registration Number
- NCT04199910
- Lead Sponsor
- University of Oulu
- Brief Summary
The aim is to evaluate the levels of oxysterols and especially 4beta-hydroxycholesterol in patients with liver cirrhosis. Three cirrhosis cohorts are recruited: patients treated with spironolactone, patients treated with rifaximin, patients without spironolactone or rifaximin. Also three other control cohorts are recruited: patients with pneumonia, patients with Crohn's disease, patients with ulcerative colitis. The effect of the cirrhosis and its medications spironolactone and rifaximin are compared to control groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Patients with cirrhosis, pneumonia, Crohn's disease or colitis ulcerosa
- Treated in the ward 42 of the Oulu University Hospital
Exclusion Criteria
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Liver cirrhosis with rifaximin There is no intervention, only research blood samples are collected - Liver cirrhosis without spironolactone or rifaximin There is no intervention, only research blood samples are collected - Liver cirrhosis with spironolactone There is no intervention, only research blood samples are collected - Pneumonia There is no intervention, only research blood samples are collected - Ulcerative colitis There is no intervention, only research blood samples are collected - Crohn's disease There is no intervention, only research blood samples are collected -
- Primary Outcome Measures
Name Time Method Blood 4beta-hydroxycholesterol concentration At the time point of the blood collection - cross-sectional. One day. Blood 4beta-hydroxycholesterol concentration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oulu University Hospital
🇫🇮Oulu, Finland