4beta-hydroksikolesteroli Maksakirroosissa
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Blood 4beta-hydroxycholesterol concentration
研究概览
简要总结
The aim is to evaluate the levels of oxysterols and especially 4beta-hydroxycholesterol in patients with liver cirrhosis. Three cirrhosis cohorts are recruited: patients treated with spironolactone, patients treated with rifaximin, patients without spironolactone or rifaximin. Also three other control cohorts are recruited: patients with pneumonia, patients with Crohn's disease, patients with ulcerative colitis. The effect of the cirrhosis and its medications spironolactone and rifaximin are compared to control groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with cirrhosis, pneumonia, Crohn's disease or colitis ulcerosa
- •Treated in the ward 42 of the Oulu University Hospital
排除标准
- 未提供
研究组 & 干预措施
Pneumonia
干预措施: There is no intervention, only research blood samples are collected (Other)
Crohn's disease
干预措施: There is no intervention, only research blood samples are collected (Other)
Ulcerative colitis
干预措施: There is no intervention, only research blood samples are collected (Other)
Liver cirrhosis with spironolactone
干预措施: There is no intervention, only research blood samples are collected (Other)
Liver cirrhosis with rifaximin
干预措施: There is no intervention, only research blood samples are collected (Other)
Liver cirrhosis without spironolactone or rifaximin
干预措施: There is no intervention, only research blood samples are collected (Other)
结局指标
主要结局
Blood 4beta-hydroxycholesterol concentration
时间窗: At the time point of the blood collection - cross-sectional. One day.
Blood 4beta-hydroxycholesterol concentration
次要结局
未报告次要终点
研究者
Janne Hukkanen
Professor
University of Oulu