Effect of Ondansetron - a preventer of nausea and vomiting on change in blood pressure and heart rate after spinal anesthesia in patients undergoing cesarean sectio

Not Applicable

Completed

• Conditions: Health Condition 1: null- Pregnant patients for cesarean section under subarachnoid block

• Registration Number: CTRI/2017/10/009964
• Lead Sponsor: MS UCMS and GTB Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-01-31
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Full term pregnant patients belonging to ASA Grade I undergoing cesarean section under subarachnoid block, having systolic blood pressure (SBP) more than 120 mm of Hg and with height of >140 cm and <170 cm.

Exclusion Criteria

Patients with history of Hypersensitivity to ondansetron, local anesthetic agents or colloids, Hypertensive disorders of pregnancy like pre-eclampsia, eclampsia, Cardiovascular diseases like MS, MR, AS; ischemic heart disease, hypertension of any cause will be excluded.

Patients taking anti-emetics like metoclopramide and having ante-partum hemmorhage, multiple gestation, hydramnios will not be included.Patients with endocrine, renal or hepatic diseases, with fetal distress and those who refused to participate will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of hypotension and bradycardia in three groupsTimepoint: Heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure and SpO2 were recorded Pre-operatively, before subarachnoid injection, After subarachnoid injection every 2 min for 20 min and then every 5 min till the end of surgery and every 30 min for 3 hrs postoperatively. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Ephedrine required to maintain SBP, Atropine required to maintain HR,Frequency of nausea and vomiting and Neonatal APGAR score <br/ ><br>Timepoint: Ephedrine when SBP less than 100 mm of Hg, Atropine when HR less than 60 bpm, nausea and vomiting perioperatively and neonatal APGAR at 1,3,5 and 10 min.