Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis

• Conditions: Language; AVM - Cerebral Arteriovenous Malformation
• Interventions: Procedure: Surgical removal of the BAVMs

• Registration Number: NCT04295980
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

At present, functional imaging studies have suggested that the Geschwind's territory (the inferior parietal lobe) is an important language area. It is the hub for semantics and phonetic language processing. However, the type and mechanism of aphasia after injury of Geschwind's territory and the subsequent recovery of language are still unclear. In our study based on brain injury model of brain arteriovenous malformation (BAVMs) resection, investigators found that the incidence of aphasia was higher after the injury of Geschwind's territory than after injury of the classical language area, and the type of aphasia was complicated, while the recovery rate of language disorder was high during follow-up. Investigators hypothesized that the type of aphasia may be associated with the type of brain connectivity damaged, and that reorganization of brain connections and brain network promote the recovery of language function. In this study, we aim to investigate the types of aphasia and their corresponding brain network changes after the resection of BAVMs located in the Geschwind's territory. Investigators will evaluate language function and collect multimodality images of the patients before resection of the lesions, as well as 7 days, 3 months and 6 months afterwards. In addition, the anatomical brain connectivity and brain network will also be analyzed. Our research will not only be a meaningful exploration for mechanisms of human language function damage and reorganization, but will also provide an important basis for the protection of brain function in neurosurgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2020-03
• Study First Submitted: 2020-03-03
• Study First Submitted QC: 2020-03-03
• Study First Posted: 2020-03-05
• Last Update Submitted: 2020-03-07
• Last Update Posted: 2020-03-10
• Primary Completion: 2022-07-01
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Signed the informed consent form;
2. The dominant hand is the right hand (evaluated by the Edinburgh hand scale);
3. BAVM located in the left inferior parietal lobe
4. No history of rupture and bleeding and neurosurgical treatment

Exclusion Criteria

1. There are implants in the body (cardiac pacemaker, artificial femoral head, etc.);
2. The dominant hand is unclear;
3. Illiterate or other patients who can not cooperate well with cognitive function tests;
4. The history of bleeding in BAVM patients within one month;
5. History of neurosurgical treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Geschwind's area BAVMs	Surgical removal of the BAVMs	-

Primary Outcome Measures

Name	Time	Method
Brain network of the brain reorganization after surgery	3 years	After surgery, we compare the brain network before and after the reorganization.
Brain network of BAVMs in Geschwind's area	2 years	compare the brain network of the Geschwind's area BAVMs patients and normal controls
Brain network after injury of Geschwind's area	2 years	compare the preoperative and postoperative brain network of Geschwind's area BAVMs.

Trial Locations

Locations (1)

Beijing Tiantan Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China