A Systematic Echography During Intubation Procedure to Predict Cardiovascular Collapse

Completed

• Conditions: Intubation

• Registration Number: NCT03184207
• Lead Sponsor: University Hospital, Brest

Brief Summary

In the operating room, most intubation procedures (IP) are scheduled and performed on hemodynamically stable patients. In the ICU, IP is frequently performed in emergent patients, because of unstable hemodynamics and/or acute respiratory failure, and complicated by a subsequent cardiovascular collapse. Transthoracic echocardiography (TTE) has become readily available in most ICUs for several years. Echocardiography enables to perform a noninvasive hemodynamic evaluation (cardiac function and volemia status).

We hypothesized that performing a TTE prior to IP may help to predict cardiovascular collapse and its components.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-13
• Study First Submitted QC: 2017-06-09
• Study First Posted: 2017-06-12
• Study Start: 2017-06-21
• Primary Completion: 2017-06-21
• Study Completion: 2018-10-19
• Status Verified: 2019-07
• Last Update Submitted: 2019-08-09
• Last Update Posted: 2019-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Patient requiring endotracheal intubation

Exclusion Criteria

• Age < 18 yrs
• Pregnancy
• Amputation of a lower limb
• Passing leg raising contraindication: intracranial hypertension with invasive monitoring, fracture of the pelvis or limbs
• Patients under administrative protective measures
• Severe cardiovascular collapse before intubation
• Severe cardiogenic pulmonary oedema

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subsequent cardiovascular collapse related to intubation	Within 15 minutes of intubation	Mean arterial pressure drop \< 60 mmHg

Secondary Outcome Measures

Name	Time	Method
Ultrasound parameters to predict fluid responsiveness	30 minutes before intubation, less than 30 minutes after intubation, 1 minutes after lifting legs and 3 hours after intubation	Transthoracic echocardiography parameters to predict fluid responsiveness

Trial Locations

Locations (3)

CHRU de Brest; 🇫🇷 Brest, France

Centre Hospitalier des Pays de Morlaix; 🇫🇷 Morlaix, France

Hôpital d'Instruction des Armées Clermont Tonnerre; 🇫🇷 Brest, France