临床试验/CTRI/2024/06/068819

CTRI/2024/06/068819尚未招募3 期

Antibacterial efficacy of combined zinc nanoparticles-calcium hydroxide root canal medication in healthy and diabetic patients with apical periodontitis - A case-control study

Shaima Misbah Shafiq1 个研究点分布在 1 个国家目标入组 60 人开始时间: 2024年6月30日最近更新: 2024年6月7日

试验速览

阶段: 3 期
状态: 尚未招募
发起方
入组人数: 60
试验地点: 1
主要终点: Analyze and quantify the antimicrobial effect of combined ZnO NP-Ca(OH)2 against common endodontic bacteria found in diabetic and healthy patients with pulp necrosis and/or apical periodontitis, by estimating the CFU of canal biofilm.

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Population (P)- Diabetic and healthy patients between the ages of 18 and 60 years, with apical periodontitis

Intervention (I)- Placement of prepared intracanal medicament (combined ZnO NP-Ca (OH)2 paste)

Comparator (C)- Placement of standard intracanal medicament (Ca (OH)2 paste)

Outcomes (O)- Reduction in the CFU of endodontic bacteria by addition of ZnO NPs to Ca(OH)2 providing a novel medicament for enhanced root canal disinfection

研究设计

研究类型: Interventional
分配方式: Na
盲法: None

入排标准

年龄范围: 18.00 Year(s) 至 60.00 Year(s)（—）
性别: All

入选标准

•Patients with controlled type 2 diabetes (HbA1c level isÂ 6.5% or below)having non-vital teeth with apical periodontitis Radiographic evidence of apical periodontitis (PAI score: 2-5).

排除标准

•Systemic factors such as pregnancy, and other co-existing immunocompromised conditions that can impair healing.
•Previously endodontically treated teeth Teeth with gross carious lesions (unrestorable), root fractures, open apex, intraoral and extraoral swelling, and extraoral sinus opening.
•Cases showing periodontal pockets deeper than 4 mm.Â Patients on antibiotic medications within 3 previous months.

结局指标

主要结局

Analyze and quantify the antimicrobial effect of combined ZnO NP-Ca(OH)2 against common endodontic bacteria found in diabetic and healthy patients with pulp necrosis and/or apical periodontitis, by estimating the CFU of canal biofilm.

时间窗: 6 months

次要结局

未报告次要终点

研究者

发起方

Shaima Misbah Shafiq

申办方类型

Other [self]

责任方

Principal Investigator

主要研究者

shaima misbah shafiq

JSS Dental College And Hospital

研究点 (1)

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