Sex Differences in Gene Expression in Human Adipose Tissue

Completed

• Conditions: Obesity; Healthy
• Interventions: Procedure: Adipose Biopsy; Procedure: Blood sample; Radiation: CT Scan; Radiation: DEXA

• Registration Number: NCT00677651
• Lead Sponsor: University of California, San Diego

Brief Summary

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand:

1. The mechanisms of differential body fat distribution in men and women

2. How body fat distribution is affected by reproductive hormones

3. The mechanisms linking fat distribution to health risks such as diabetes

Detailed Description

Not available

Study Timeline

• Study Start: 2008-04
• Study First Submitted: 2008-05-12
• Study First Submitted QC: 2008-05-12
• Study First Posted: 2008-05-14
• Status Verified: 2009-08
• Primary Completion: 2009-08
• Study Completion: 2009-08
• Last Update Submitted: 2009-08-17
• Last Update Posted: 2009-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Caucasian men and women 20-35 years of age
• Lean (BMI less than 25)
• Obese (BMI 30-35)

Exclusion Criteria

• Hormonal birth control
• Pregnancy
• Smokers
• History of diabetes, kidney, liver or thyroid disease
• History of cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
2	Adipose Biopsy	Five caucasian men
1	Adipose Biopsy	Five caucasian women
1	Blood sample	Five caucasian women
1	DEXA	Five caucasian women
1	CT Scan	Five caucasian women
2	CT Scan	Five caucasian men
2	Blood sample	Five caucasian men
2	DEXA	Five caucasian men

Primary Outcome Measures

Name	Time	Method
Adipose and blood sampling	1 year

Secondary Outcome Measures

Name	Time	Method
CT scan and DEXA scan	1 year

Trial Locations

Locations (1)

UCSD; 🇺🇸 La Jolla, California, United States