Effects of propofol on microcirculation in childre

Completed

• Conditions: circulatie; microcirculation

• Registration Number: NL-OMON43768
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

-procedural sedation with propofol
-children 8-18 years

Exclusion Criteria

no written informed consent

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is to determine the effect of propofol on buccal and<br /><br>sublingual microcirculation in children.<br /><br>Both buccal and sublingual microcirculations will be evaluated with a CytoCam<br /><br>an optical spectroscopic sensor-based digital video imaging instrument<br /><br>(Braedius Medical BV, The Netherlands). The buccal capillary density will be<br /><br>quantified by mean buccal capillary density and functional capillary density<br /><br>(FCD). Sublingual microcirculation profile consists of blood vessel diameter<br /><br>(BVd), proportion of perfused vessels (PVV), perfused vessel density (PVD),<br /><br>microcirculatory flow index (MFI) and total vascular density (TVD).<br /><br>Macrocirculation will be monitored by blood pressure and heart rate and<br /><br>hemoglobin oxygen saturation by pulse oximetry.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>