The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

Completed

• Conditions: 10024967; cortical stress response; brain activation; 10028593; 10029305

• Registration Number: NL-OMON30239
• Lead Sponsor: Hogeschool Zuyd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Age > 18
2. No cardiac impairments
3. Free of neurological and psychopathological impairment, including
• Most psychopathologies as diagnosed by DSM-IV criteria (depression, anxiety disorders, attention deficit hyper activity disorder (ADHD), schizophrenia, autistic spectrum disorders (PDD-NOS)
• diseases of the central nervous system in general (Parkinson disease, cerebro vascular accident (stroke), multiple sclerosis, amyotrophic lateral sclerosis, epilepsy)
• other diseases which are known to affect the QEEG: chronic fatigue syndrome (CFS), fibromyalgia, whiplash, burn-out syndrome, migraine

Exclusion Criteria

1. (Time of) use of medication affecting brain activity
2. Extreme fatigue at time of experiment
3. Excessive use of drugs in past or present

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Median Power derived from Fouriertransform of QEEG<br /><br>2) Proportion of various frekquencies (theta to beta-deel) making up the QEEG<br /><br>3) de baseline blood-flow in the fingertip, ans flow-changes induced by a local<br /><br>challenge with nitroprusside and acetylcholine.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>4) CO-exhalation and allantoine in urine as markers for oxidative stress</p><br>