Genotype effect on Chest surgery

Not Applicable

Conditions: Health Condition 1: J80- Acute respiratory distress syndrome

Registration Number: CTRI/2022/07/043800

Lead Sponsor: Department of Anaesthesiology

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

both sexes;

aged 18 to 70 years old;

ASA I and II

normal renal function with creatinine clearance >30 mL/min.

Exclusion Criteria

(I) previous administration of antidepressants, anticonvulsants, or opioids before surgery; (II) serious medical conditions (uncontrolled heart, lung, liver or kidney disease or diabetes); (III) a history of angioedema; (IV) pregnant or nursing; (V) problematic in receiving epidural anaesthesia (spinal deformity, or previous anticoagulation therapy).

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the to investigate the efficacy of pre-emptive analgesia comprised of pre-gabalin versus naproxen in thoracotomy while secondary outcome will be to find out the effects of the COMT gene on modulating pain and its association in thoracotomy along with <br/ ><br> Assessment of intra-operative hemodynamic stability <br/ ><br>and post-operative safety and efficacy <br/ ><br>Timepoint: 48 hrs

Secondary Outcome Measures

Name	Time	Method
Patients will be asked to rate their pain (NRS) for the previous 24 hours and their sleep interference rate (SIR) during the previous night, and circled numbers which best described on an 11-point scale, where 0 indicated no pain or sleep interference and 10 will be the worst possible pain or the greatest sleep interference. The NRS and SIR will be assessed on the morning of the 1st, 3rd and 5th day after surgery. Each patient will be visited by a trained questioner who will be blinded to the treatment groups and instructed to fill out the evaluation form.Timepoint: 4HRS