Comparing Three Different Doses of Intrathecal Ketamine
- Conditions
- Ketamine Causing Adverse Effects in Therapeutic Use
- Interventions
- Registration Number
- NCT05074823
- Lead Sponsor
- Assiut University
- Brief Summary
The aim of this study is to compare the postoperative analgesic effect of three different doses of intrathecal ketamine as an adjuvant to bupivacaine in patients undergoing knee arthroscopy.
- Detailed Description
A meta-analysis of adult human randomized controlled studies that compared single dose perioperative intrathecal ketamine plus intrathecal bupivacaine to bupivacaine alone in spinal anesthesia suggests that there is a benefit to using intrathecal ketamine as an adjunct to bupivacaine in multimodal analgesia. However, there are still knowledge and experience gaps regarding neuraxial ketamine dosing in this regard.
Aim of the study:
The aim of this study is to compare the postoperative analgesic effect of three different doses of intrathecal ketamine as an adjuvant to bupivacaine in patients undergoing knee arthroscopy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 105
- Age: 18-70 years.
- BMI: 20-30 kg.m2
- Sex: both males and females.
- ASA physical status: I-III.
- Operation: knee arthroscopy.
- Patient's refusal to participate in the study.
- Aged less than 18 years,
- known allergy to L.A.,
- Coagulopathy or thrombocytopenia,
- height less than 150 cm, morbidly obese infection at the site of injection.
- Chronic pain syndromes,
- pregnant woman
- Patients on regular use of analgesic or who received analgesic 24 h before surgery.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ketamine 0.1 Ketamine 0.1 mg Group I: will include 35 patients, will receive 3mL of bupivacaine (heavy) 0.5% in addition to 0.5 ml of a preservative-free ketamine 0.1 mg/kg Ketamine 0.3 Ketamine 0.3 mg Group III will include 35 patients, will receive 3mL of bupivacaine (heavy) 0.5% in addition to 0.5 ml of a preservative-free ketamine 0.3 mg/kg Ketamine 0.2 Ketamine 0.2 mg Group II will include 35 patients, will receive 3mL of bupivacaine (heavy) 0.5% in addition to 0.5 ml of a preservative-free ketamine 0.2 mg/kg
- Primary Outcome Measures
Name Time Method Time to first analgesic request First 24 hours From the time of intrathecal administration of the drug to the time of patient needs the first rescue analgesic drug
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assiut University hospital
🇪🇬Assiut, Egypt