pharmacokinetics and pharmacodynamics study of intraveneous acetaminophe
Phase 3
- Conditions
- Patients who undergo head neck and oral surgery without nerve block or epidural anesthesia
- Registration Number
- JPRN-UMIN000030006
- Lead Sponsor
- Tohoku University
- Brief Summary
As a result of examining the results of NRS in 3 groups and postoperative analgesics and the characteristics of the blood concentration transition curve, when intravenous APAP 1000 mg is used intraoperatively and postoperatively, the analgesic effect was high with the administration method that combined rapid single administration and continuous administration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 51
Inclusion Criteria
Not provided
Exclusion Criteria
1.History of allergy to acetaminophen 2.History of aspirin asthma 3.Oral use of carbamazepine/phenobarbital/phenytoin/primidone/rifampicin 4.Psychoneurotic disorders 5.Psychiatric pharmacotherapy 6.Liver or advanced renal dysfunction 7.Alcohol drinkers and adddiction patient 8.Pregnant woman/breast-feeding 9.Those who were considered inadequate
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood concentration of acetaminophen
- Secondary Outcome Measures
Name Time Method VRS VAS NRS