Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Other: Isometric exercise training

• Registration Number: NCT05025202
• Lead Sponsor: Canterbury Christ Church University

Brief Summary

A randomized, sham-controlled intervention measuring the effects of isometric exercise training (IET) on blood pressure and cardiac autonomics.

IET has been proven effective in a plethora of randomized trials, but very little research has employed a sham-controlled design. This researched involved the recruitment of 30 participants who completed a 4 week IET intervention, sham control of the IET intervention, or a non-intervention control period. Pre and post blood pressure and cardiac autonomic measures were acquired and analysed.

The hypothesis of this trial was a significant effect of IET on blood pressure, with no such effects following the sham control or normal control interventions.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-15
• Primary Completion: 2019-12-29
• Study Completion: 2020-09-11
• Status Verified: 2021-08
• Study First Submitted: 2021-08-16
• Study First Submitted QC: 2021-08-23
• Study First Posted: 2021-08-27
• Last Update Submitted: 2021-08-31
• Last Update Posted: 2021-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Healthy with no significant health conditions contraindicating exercise
• Over 18 years of age
• Physically inactive

Exclusion Criteria

• Achieving current physical activity guidelines
• Abnormal resting ECG
• under 18

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham	Isometric exercise training	Participants allocated to this arm performed 4 weeks of isometric wall squat training, but the training prescription was intentionally provided at an insufficient intensity to achieve any physiology stimulus.
IET	Isometric exercise training	Participants allocated to this arm performed 4 weeks of isometric wall squat exercise training, 3 times per week.

Primary Outcome Measures

Name	Time	Method
Blood pressure (systolic, diastolic and mean BP)	At the end of the intervention (post 4 weeks)	Resting office blood pressure measured at brachial artery
Cardiac autonomics measured at HRV	At the end of the intervention (post 4 weeks)	LF and HF power spectral measures

Secondary Outcome Measures

Name	Time	Method
continuous 5-minute blood pressure (systolic, diastolic and mean BP)	At the end of the intervention (post 4 weeks)	5 minute mean of resting blood pressure measured beat-to-beat

Trial Locations

Locations (1)

Canterbury Christ Church University; 🇬🇧 Canterbury, Kent, United Kingdom