Development of a Novel Anti-caries Chewing Gum
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dental Plaque
- Sponsor
- University of Toronto
- Enrollment
- 30
- Primary Endpoint
- Change in target species of the oral microbiome
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.
Detailed Description
The goal of this project is to develop a pre-biotic chewing gum that is designed to promote a healthy oral microbiome. The gum will contain compounds that will: a) be unable to be converted to acids; b) target the cariogenic S. mutans population; c) promote the stability of a healthy environment by modulating plaque pH via base-generating compounds; d) promote tooth remineralization by increasing saliva flow and by addition of calcium phosphate.
Investigators
Dennis Cvitkovitch
Professor
University of Toronto
Eligibility Criteria
Inclusion Criteria
- •In good general health, no relevant medical history
- •No dental treatment in the previous 3 months
- •Willing to participate and give written informed consent
Exclusion Criteria
- •Patients undergoing fixed or removable orthodontic treatment
- •Patients using removable prosthesis
- •History of head and neck radiation therapy
- •History of adverse reaction or allergies to xylitol or other additives
- •Antibiotics use in the last four weeks
- •Patients with any systemic diseases
- •Xerostomia (also medication-induced)
- •Currently using any mouth rinse
- •Pregnant or breastfeeding women
Outcomes
Primary Outcomes
Change in target species of the oral microbiome
Time Frame: 28 days
Total microbiome analyses will be performed at the beginning and end of the study (4 weeks) to assess total cultivable flora, levels of S. mutans, S. salivarius, and P. gingivalis in addition to using qRT-PCR from plaque and saliva samples