Effect of Standard Care Rehabilitation Versus Interval Treadmill Training After Myocardial Infarction

Not Applicable

Completed

• Conditions: Myocardial Infarction
• Interventions: Behavioral: Exercise training

• Registration Number: NCT00235339
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The purpose of this study is to investigate the effect of the standard rehabilitation offered by three hospital rehabilitation units in Norway, one in Trondheim, one in Ålesund and one in Levanger, compared to an interval treadmill training program. The subjects participating in the study are patients with myocardial infarction. The maximal oxygen consumption of the subjects will be tested before and after the training period.

Detailed Description

The purpose of this study is to investigate the effect of the standard rehabilitation offered by three hospital rehabilitation units in Norway, one in Trondheim, one in Ålesund and one in Levanger, compared to an interval treadmill training program. The subjects participating in the study are patients with myocardial infarction. The maximal oxygen consumption of the subjects will be tested before and after the training period.

Primary outcome: Maximal oxygen consumption Secondary outcomes: Blood values (for endothelial function, blood lipids, etc), flow mediated dilatation, quality of life (SF 36 and MacNew), weight, BMI, heart rate fall 1 minute after stopping the maximal treadmill test.

Study Timeline

• Study Start: 2005-10
• Study First Submitted: 2005-10-07
• Study First Submitted QC: 2005-10-07
• Study First Posted: 2005-10-10
• Primary Completion: 2008-02
• Study Completion: 2009-12
• Status Verified: 2012-05
• Last Update Submitted: 2012-05-11
• Last Update Posted: 2012-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

• Myocardial infarction 2-12 weeks ago

Exclusion Criteria

• Heart failure
• limitations to walking on a treadmill
• failure to reach a maximal pre-test(> NYHA class II)
• uncontrolled hypertension
• COPD
• pregnancy
• kidney failure (creatinin > 140)
• drug abuse
• left ventricle EF < 30%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Exercise training	Standard exercise training rehabilitation at the hospital
2	Exercise training	Interval exercise training on treadmills, with high intensity

Primary Outcome Measures

Name	Time	Method
change in maximal oxygen consumption	baseline, after intervention and at 6 months	At baseline, following intervention and at 6 months after the intervention. An additional follow-up test will be conducted in all patients who want to participate during 2009.

Secondary Outcome Measures

Name	Time	Method
quality of life	baseline, after intervention and at 6 months
flow mediated dilatation	baseline, after intervention and at 6 months	flow mediated dilatation (endothelial function)
echocardiography	baseline, after intervention and at 6 months
blood markers	baseline, after intervention and at 6 months

Trial Locations

Locations (3)

Sykehuset Levanger; 🇳🇴 Levanger, Norway

St.Olav Hospital; 🇳🇴 Trondheim, Norway

Ålesund Hospital; 🇳🇴 Ålesund, Norway