Feasibility of Obtaining and Characterizing Circulating Tumorigenic Cells in Patients With Pancreatic Adenocarcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 83
- 试验地点
- 5
- 主要终点
- isolating and enriching circulating tumorigenic cells
研究概览
简要总结
The purpose of this study is to collect blood samples and study cancer cells found in these blood samples from patients with pancreatic cancer. Prior research has discovered that tumor cells can be collected from the blood of patients with pancreatic and other cancers.
The physicians have developed techniques for isolating and analyzing cancer cells using a simple blood test. They will study how these cells relate to how chemotherapy works. They hope to use this information to guide choices of treatment for patients in the future.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological or cytological diagnosis of pancreatic adenocarcinoma, confirmed at MSKCC.
- •Patient eligible for chemotherapy treatment.
- •Prior surgery, chemotherapy and/or radiation therapy for pancreatic adenocarcinoma is permitted.
- •ECOG performance status 0-
- •A minimum age of 18 years old.
排除标准
- •Known to be HIV positive on antiretroviral therapy
- •Prior organ allograft
- •Any medical or psychiatric condition that may interfere with the ability to comply with protocol procedures
结局指标
主要结局
isolating and enriching circulating tumorigenic cells
时间窗: 1 year
A 10 mL blood sample will be drawn from participants prior to starting chemotherapy treatment. circulating tumorigenic cells from the peripheral blood of eligible pancreatic cancer patients. During the 1 year following enrollment, in the setting of disease progression, a subsequent 10 mL blood sample may be drawn from participants prior to changing chemotherapy treatment.
次要结局
- successful gene expression profiling(1 year)